| 下丘脑弓状核损毁对大鼠某些组织Se—GSH—Px活性和LPO水平的影响 |
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| 引用本文： | 龚守良,孙铁华,吕喆. 下丘脑弓状核损毁对大鼠某些组织Se—GSH—Px活性和LPO水平的影响[J]. 吉林大学学报(医学版), 1992, 0(2) |
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| 作者姓名： | 龚守良 孙铁华 吕喆 |
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| 作者单位： | 白求恩医科大学放射生物教研室(龚守良，孙铁华)，白求恩医科大学放射生物教研室(吕喆) |
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| 摘 要： | 本研究证实,弓状核损伤后大鼠睾丸和肾上腺谷胱甘肽过氧化酶(Se—GSH—Px)活性明显降低(P<0.05),而脂质过氧化物(LPO)水平在两种组织中都不同程度增高;肝脏中两种物质都非常明显增高(P<0.01);脾脏中两者变化不明显。提示,下丘脑弓状核损毁可影响大鼠睾丸、肾上腺和肝脏Se—GSH—Px活性和LPO水平变化,而对脾脏无影响。
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| 关 键 词： | 弓状核 谷氨酸钠 谷胱甘肽过氧化酶 脂质过氧化物 |
EFFECT OF HYPOTHALAMIC ARCUATE NUCLEUSLESIONS ON Se-GSH-Px ACTIVITY AND LPOLEVEL IN SOME TISSUES IN RATS |
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| Gong Shouliang,Sun Tiehua,Lu zhe. EFFECT OF HYPOTHALAMIC ARCUATE NUCLEUSLESIONS ON Se-GSH-Px ACTIVITY AND LPOLEVEL IN SOME TISSUES IN RATS[J]. Journal of Jilin University: Med Ed, 1992, 0(2) |
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| Authors: | Gong Shouliang Sun Tiehua Lu zhe |
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| Affiliation: | Department of Radiation Biology |
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| Abstract: | It was demonstrated that neonatal administration of monosodium glutamin (MSG) in rats resulted in clearly defined lesions in the hypothalamic arcuate nucleus. The present study showed that Se-GSH-Px activity decreased significantly (P<0. 05), and IPO level increased in various degrees in the testes and adrenal; while in the liver, both increased very significantly (P<0. 01). However in the spleen, both did not show any significant changes. These results suggest that Se-GSH-Px activity and LPO level may change in the testes, adrenal and liver bat not in the spleen when hypothalamic arcuate nucleus is damaged in rats. |
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| Keywords: | Arcuate nucleus Monosodium glutamine (MSG) Se-GSH-Px LPO |
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