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CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice
Authors:Yang Jun-Qi  Chun Taehoon  Liu Hongzhu  Hong Seokmann  Bui Hai  Van Kaer Luc  Wang Chyung-Ru  Singh Ram Raj
Affiliation:Autoimmunity and Tolerance Laboratory, Department of Internal Medicine, University of Cincinnati, and Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA.
Abstract:Mechanisms responsible for the development of autoimmune skin disease in humans and animal models with lupus remain poorly understood. In this study, we have investigated the role of CD1d, an antigen-presenting molecule known to activate natural killer T cells, in the development of inflammatory dermatitis in lupus-susceptible MRL-lpr/lpr mice. In particular, we have established MRL-lpr/lpr mice carrying a germ-line deletion of the CD1d genes. We demonstrate that CD1d-deficient MRL-lpr/lpr mice, as compared with wild-type littermates, have more frequent and more severe skin disease, with increased local infiltration with mast cells, lymphocytes and dendritic cells, including Langerhans cells. CD1d-deficient MRL-lpr/lpr mice had increased prevalence of CD4(+) T cells in the spleen and liver and of TCR alpha beta (+)B220(+) cells in lymph nodes. Furthermore, CD1d deficiency was associated with decreased T cell production of type 2 cytokines and increased or unchanged type 1 cytokines. These findings indicate a regulatory role of CD1d in inflammatory dermatitis. Understanding the mechanisms by which CD1d deficiency results in splenic T cell expansion and cytokine alterations, with increased dermal infiltration of dendritic cells and lymphocytes in MRL-lpr/lpr mice, will have implications for the pathogenesis of inflammatory skin diseases.
Keywords:Autoimmunity  CD1d  Dermatitis  Lupus  NKT cells
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