| 依那普利降低老龄鼠心房颤动诱发率的研究 |
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| 引用本文： | 刘英明,杨晔,费宇行,曹毅,卢才义. 依那普利降低老龄鼠心房颤动诱发率的研究[J]. 天津医药, 2010, 38(1) |
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| 作者姓名： | 刘英明 杨晔 费宇行 曹毅 卢才义 |
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| 作者单位： | 1. 海军总医院心内科,北京,100037
2. 解放军总医院老年心血管病研究所 |
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| 摘 要： | 目的:研究依那普利对老龄鼠心房颤动(房颤)诱发率的影响.方法:雄性老龄Wistar大鼠随机分为对照组和实验组,对照组常规饲养,实验组加喂依那普利.3个月后动物麻醉开胸暴露心脏.测量右房有效不应期.测量窦房结传导时间(SCT)和窦房结恢复时间(SRT)评价窦房结功能.采用心房短阵刺激评价房间传导时间(IACT)和心房对刺激的反应.用放免法测量血浆和心房组织血管紧张素Ⅱ(AngⅡ)浓度.取心房组织制作切片,Masson染色,测量纤维组织占总区域的百分比.结果:实验组IACT和SRT较对照组缩短(P ＜ 0.01或P ＜ 0.05).对照组有9例诱发出房颤,实验组有4例诱发出房颤(P ＜ 0.05).实验组左、右房组织匀浆AngⅡ浓度较对照组降低(均 P ＜ 0.01).实验组大鼠左房和右房纤维化程度均较对照组明显减轻(均P ＜ 0.01).结论:老龄鼠长期应用依那普利后房颤诱发率降低,窦房结功能改善.
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| 关 键 词： | 依那普利 心房颤动 肾素-血管紧张素系统 纤维化 大鼠 |
Enalapril Decreased Inducible Atrial Fibrillation in Old Rats |
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| LIU Yingming,YANG Ye,FEI Yuxing,CAO Yi,LU Caiyi. Enalapril Decreased Inducible Atrial Fibrillation in Old Rats[J]. Tianjin Medical Journal, 2010, 38(1) |
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| Authors: | LIU Yingming YANG Ye FEI Yuxing CAO Yi LU Caiyi |
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| Affiliation: | LIU Yingming,YANG Ye,FEI Yuxing,CAO Yi,LU Caiyi Department of Cardiology,Navy General Hospital,Beijing 100037,China |
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| Abstract: | Objective:To study the effect of enalapril on inducible atrial fibrillation (AF) in old rats. Methods:Old male Wistar rats were randomly divided into control group (n=12) and experimental group (n=13). Rats in control group were fed routinely. Rats were fed with enalapril besides normal diet in experimental group for three months. Rats were then anesthetized,thoracotomy was performed and pericardium was opened to expose heart. Right atrium effective refractory period (ERP) was measured. Sinus conduction tim... |
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| Keywords: | Wistar enalapril atrial fibrillation renin-angiotensin system fibrosis rats Wistar |
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