| 糖尿病性微血管病的临床病理生理 |
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| 引用本文： | 金惠铭,胡仁明.糖尿病性微血管病的临床病理生理[J].中国病理生理杂志,2007,23(2):399-402. |
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| 作者姓名： | 金惠铭 胡仁明 |
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| 作者单位： | 1复旦大学上海医学院生理与病理生理学系血管分子生物学实验室， 上海 200032；
2 复旦大学附属华山医院糖尿病与内分泌研究所， 上海 200040 |
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| 基金项目： | 国家自然科学基金;上海市科委资助项目 |
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| 摘 要： | 糖尿病患者大多死于心血管并发症。糖尿病心血管并发症的发生发展与糖尿病性微血管病（diabetic microangiopathy）密切相关。本文将针对糖尿病性微血管病的临床病理生理展开讨论。
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| 关 键 词： | 微血管病 氧化性应激 蛋白激酶C 过氧化酶体激增剂活化受体-γ |
| 文章编号： | 1000-4718（2007）02-0399-04 |
| 收稿时间： | 2006-9-6 |
| 修稿时间： | 2006-09-062006-09-25 |
Clinical pathophysiology of diabetic microangiopathy |
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| JIN Hui-ming,HU Ren-ming.Clinical pathophysiology of diabetic microangiopathy[J].Chinese Journal of Pathophysiology,2007,23(2):399-402. |
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| Authors: | JIN Hui-ming HU Ren-ming |
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| Institution: | 1Department of Physiology & Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, China; 2Institute of Endocrinology and Diabetes, Huashan Hospital, Fudan University, Shanghai 200040, China. E-mail: hmjin@shmu.edu.cn |
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| Abstract: | In present review, the history of microangiopathy discovery and it’s modern concept were introduced and the pathophysiological changes of some vital organs in diabetes were analyzed. The roles of oxidation stress, distur bances of microvascular functions, microvascular endothelial cell damage, PKC and PPARγ in pathogenesis of diabetic microangiopathy were also discussed. |
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| Keywords: | Microangiopathy Oxidative stress Protein kinase C Peroxisome proliferator-activated receptor γ |
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