| 大肠癌及大肠腺瘤细胞核DNA定量研究 |
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| 引用本文： | 盛传伦,郑泽霖,刘士新,张谦. 大肠癌及大肠腺瘤细胞核DNA定量研究[J]. 吉林大学学报(医学版), 1992, 0(3) |
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| 作者姓名： | 盛传伦 郑泽霖 刘士新 张谦 |
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| 作者单位： | 白求恩医大第三临床医学院，白求恩医大第三临床医学院，吉林省肿瘤医院，长春市卫校 |
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| 摘 要： | 本文应用显微分光光度计测定32例大肠活检粘膜细胞核DNA含量。结果表明:11例大肠腺癌细胞核DNA含量高于正常肠粘膜上皮细胞核DNA含量;18例大肠息肉细胞核DNA含量介于正常肠粘膜和大胸腺癌之间(P<0.01)。检测细胞核DNA含量,可用于判定大肠癌及癌前病变,并可作为判定早期大肠癌的定量指标。
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| 关 键 词： | 大肠癌 癌前病变 DNA含量 显微分光光度计 |
QUANTITATIVE STUDY ON NUCLEAR DNA IN COLORECTAL CARCINOMA AND COLONIC ADENOMA |
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| Sheng Chuanlun,Zheng Zelin. QUANTITATIVE STUDY ON NUCLEAR DNA IN COLORECTAL CARCINOMA AND COLONIC ADENOMA[J]. Journal of Jilin University: Med Ed, 1992, 0(3) |
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| Authors: | Sheng Chuanlun Zheng Zelin |
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| Affiliation: | The Third Teaching Hospital |
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| Abstract: | In this experiment, nuclear DNA content in bioptic colonic mucous membrane cells was microspectrophotometric ally determined in 32 patients suffering from malignant and benign col-orectal diseases. The results showed that the nuclear DNA content in 11 patients with adenomas of the large intestine was higher than that in the normal colonic mucous membrane cells and that the nuclear DNA content in 18 patients suffering from colonic polyps was intermediate between that of the normal colonic mucous membrane cells and the colonic adenoma (P<0. 01). These results suggest that mi-crospectrophotometric measurement of nuclear DNA content may serve as an objective quantitative method for diagnosis of malignant and precancerous colorectal diseases. We have found that the nuclear DNA content may serve as the quantitative index for early colorectal carcinoma. |
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| Keywords: | Colorectal cancer Precancer lesion DNA content Microdensitometer |
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