Regulation of substance P by nerve growth factor: disruption by capsaicin |
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Authors: | Matthew S. Miller Stephen H. Buck I. Glenn Sipes Henry I. Yamamura Thomas F. Burks |
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Affiliation: | Brain Research Institute of the University of Zürich, Zürich, Switzerland |
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Abstract: | Capsaicin depleted substance P from guinea pig dorsal root ganglia and inhibited the retrograde axoplasmic transport of nerve growth factor (NGF). Doses of capsaicin which depleted substance P also inhibited the retrograde axoplasmic transport of NGF. Inhibition of the retrograde transport of NGF by capsaicin preceded substance P depletion. Supplementation of guinea pigs with mouse NGF completely prevented capsaicin-induced substance P depletion. It is concluded that capsaicin depletes substance P from primary afferent neurons of the adult guinea pig by altering the availability of NGF. The data support a role for NGF in the normal maintenance of neuropeptide levels in some sensory neurons in the adult animal. |
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Keywords: | capsaicin substance P nerve growth factor |
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