三种药物促进宫颈成熟的临床应用观察

目的 观察普贝生、米索前列醇、缩宫素三种促进宫颈成熟药物的有效性和安全性。方法采用随机对照研究方法，将180例初产妇分为3组，A组：普贝生；B组：小剂量米索前列醇组；C组：缩宫素组。比较三组用药前、后4、8、12h宫颈Bishop评分，用药后分娩情况、胎儿窘迫及新生儿窒息的发生率。结果A、B、C三组的有效率分别为88．3％、85．0％、35．0％；用药后剖宫产率分别为21．7％、25．0％、60．0％。A，B组分别与C组比较差异有统计学意义（P〈0．05）。结论普贝生及米索前列醇均是安全、有效的，临床应用成功率高；缩宫素则疗效欠佳。

The clinical application observation of three drugs to promote cervical ripening

Objective To observe the efficacy and safety of three drugs(dinoprostone suppositories,misopmstol and oxytocin) to promote cervieal ripening.Methods A randomized control study method was used.The 180 primipara was divided into 3 groups.Group A:dinoprostone suppositories,Group B:low-dose misoprostol,Group C:oxytocin.The maternal cervical Bishop score of three drugs being used before and after 4,8,12 h was compared between the three groups,as well as the labor situation,the rate of fetal distress and neonatal asphyxia after the drugs.Results The effective rates of groups A,B,C were 88.3%,85.0%,35.0%.The cesarean section rates of three groups were 21.7%,25.0%,60.0%.There was significantly different between groups A,B with group C(P＜0.05).Conclusion Dinoprostone suppositories and misoprostol were safe and effective,and they had a high success rate of clinical application.Then Oxytocin was ill effect.