超声新技术评估化学治疗乳腺癌致左心室功能损伤研究进展

化学治疗(简称化疗)是乳腺癌常规治疗手段之一,在有效抑制肿瘤的同时亦会导致心脏损伤。化疗所致心脏损伤的最直接表现是左心室收缩功能减低。目前临床评价左心室功能最常用方法为超声测量左心室射血分数(LVEF),而LVEF只有在心肌严重损伤情况下才会明显下降,此时多已错过最佳干预时机。随着超声技术的进步,一系列超声新技术已用于检测心功能,并能早期发现心肌损伤。本文对超声新技术评估乳腺癌化疗致左心室功能损伤研究进展进行综述。

Advancements of new ultrasound techniques in evaluation on left ventricular dysfunction caused by chemotherapy of breast cancer

Chemotherapy is one of the conventional treatment methods for breast cancer, which effectively inhibit the tumor but also lead to heart injury. The most direct manifestation of chemotherapy-induced heart injury is the decrease of left ventricular systolic function. At present, the most commonly used indicator for clinical evaluation of left ventricular function is echocardiography measured left ventricular ejection fraction (LVEF), which decreasing significantly only in the case of severe myocardial injury, but the best opportunity of intervention has already missed at that time. With the developments of ultrasound technologies, a series of new ultrasound techniques have been used to observe cardiac function, which can detect myocardial injury at early stage. The advancements of new ultrasound techniques in evaluation on left ventricular dysfunction caused by chemotherapy for breast cancer were reviewed in this article.