Tissue characterization of intracranial tumors by magnetization transfer and spin-lattice relaxation parameters in vivo

T1s and magnetization transfer (MT) parameters of 36 intracranial tumors were determined in vivo at 0.1 T to assess their use in tissue characterization. The mobile water relaxation times (T1_w) did not differ between tumor groups, whereas the T1s, the apparent MT relaxation times (T1_a), and the parameters MT contrast (MTC) differed significantly between several tumor types. The MT rates (R_wm) demonstrated the most significant differences; R_wm values could reliably separate high grade and low grade gliomas. T1_ws of the tumors were commonly in the same range as that of normal gray matter, whereas other parameters differed from those of normal brain. The results indicate that MT rates are superior to other parameters in the characterization of intracranial tumors and may be also useful clinically in the grading of gliomas.