川崎病患儿血浆D-二聚体与纤维蛋白原的变化及临床意义

目的 通过检测川崎病患儿D-二聚体和纤维蛋白原(Fib)含量,探索D-二聚体和纤维蛋白原改变与川崎病合并冠状动脉病变之间的关系.方法 采用酶联免疫吸附实验(ELISA)分别检测65例川崎病患儿、30例健康对照组小儿的D-二聚体和纤维蛋白原含量,并同时检测血小板计数(PLT).结果 川崎病组的D-二聚体和纤维蛋白原含量高于健康对照组,差异有统计学意义(P<0.01);合并冠状动脉病变(CAL)组D-二聚体和纤维蛋白原含量高于无冠状动脉损伤(NCAL) 组, 差异有统计学意义(P<0.01);D-二聚体和纤维蛋白原含量与血小板计数无相关性.结论 D-二聚体和纤维蛋白原与川崎病冠状动脉损伤有着密切的关系,对川崎病合并冠状动脉病变具有较好的预测价值.

Change of plasma D-dimer and Fib in Kawasaki disease and its clinical significance

Objective To discuss the relationship between plasma D-dimer,Fib and Kawasaki disease(KD) patients with coronary artery lesion(CAL) complication by examining plasma D-dimer and Fib in KD patients. Methods The levels of plasma D-dimer and Fib was measured by enzyme linked immunosorbent assay and platelet count was calculated among 65 KD patients and 30 healthy children. Results The levels of plasma D-dimer and Fib was significantly higher in KD group than in the healthy group(P<0.01).Plasma D-dimer and Fib in CAL group was significantly higher than in non-CAL group(P<0.01).Plasma D-dimer and Fib in KD group had no correlation with platelet. Conclusion D-dimer and Fib is related to KD.The high levels of D-dimer and Fib is related to the severity of vascular damage in KD,which may be a sensitive predictor of coronary artery lesion.