黄芪注射液治疗甲巯咪唑引起甲亢患者白细胞减少症评价

目的:评价黄芪注射液治疗甲巯咪唑引起白细胞减少症的临床疗效及安全性。方法:将49例甲巯咪唑治疗甲状腺功能亢进症引起白细胞减少症患者随机分成A、B两组,A组(25例):利血生20 mg,1 d 3次;鲨肝醇100 mg,1 d 3次,连用4周。B组(24例):在A组用药的基础上加黄芪注射液40 m L入于5%葡萄糖注射液250 m L中静滴,每天1次,连用4周。观察两组用药前后外周白细胞计数的变化。结果:治疗前及治疗第1周末两组患者WBC均无显著差异;治疗第2~4周两组WBC均有统计学差异(P0.05),以B组较A组多。纵向比较方面,B组的变化(P=0.021)亦较A组明显(P=0.039)。有效率方面,B组总有效率87.5%,经秩和检验发现,两组的总有效率比较有显著意义(H=-3.012,P=0.031)。结论:黄芪注射液治疗甲巯咪唑引起白细胞减少症有显著疗效,且无明显副反应。

Analysis on Astragalus Injection for Hyperthyroidism Patients with Leukopenia Caused by Thiamazole

Objective ： To evaluate the clinical curative effect and safety of Astragalus Injection to treat hyperthyroidism patients with leukopenia caused by thiamazole. Methods ： 49 cases of hyperthyroidism patients with leukopenia caused by thiamazole patients were randomly divided into group A and B Group A （ 25 cases ）： leucogen 20 mg, three times a day; hatyl alcohol 100 rag, three times a day for continuous 4 weeks. Group B （ 24 cases ）： on the basis of the treatment in group A,40 mL Astragalus Injection in 5% glucose solution 250 ml for intravenous infusion, once a day, for continuous 4 weeks. We observed two groups＇peripheral white blood cell count. Results： Before treatment and at the 1st treatment weekend, two groups＇WBC counts had no significant difference. 2-4 weeks after treatment, the WBC counts in two groups were statistically significant （P〈0.05）and there were more in group B than in group A. The longitudinal comparisons showed group B （ P=0.021 ） was significant than group A （ P= 0.039 ）. B group＇s total effective rate was 87.5%. Through the rank test, the total effective rate of the two groups had significance （ H=3.012, P=3.012 ）. Conclusion ： Astragalus Injection has significant curative effect on hyperthyroidism patients with leukopenia caused by thiamazole and no obvious side effects.