血清白介素6与胱抑素C联合检测对糖尿病肾脏疾病早期的诊断价值

目的探讨血清白介素6(IL-6)和胱抑素C(CysC)联合检测对糖尿病肾脏疾病(DKD)早期诊断的价值。方法在164例糖尿病(DM)患者中,120例尿白蛋白排泄率(UAER)<20μg/min无早期肾损伤者为DM组,44例UAER 20～200μg/min的DKD患者为DKD组;同时选取50例健康体检者作为对照组。分别测定三组入选者的IL-6和CysC水平,并进行统计学分析。结果与健康对照组相比,DM组和DKD组的IL-6、CysC和hs-CRP水平均高于对照组(P<0.01);与DM组相比,DKD组以上三项检测指标水平均高于DM组(P<0.01);IL-6和CysC联合检测阳性率明显高于单项检测(P<0.05);IL-6和CysC阳性组hs-CRP水平明显高于阴性组(P<0.01)。结论联合检测IL-6和CysC有利于提高DKD检测的阳性率,对DKD的早期诊断有意义;IL-6和CysC对疾病活动的判断有重要价值。

Diagnostic value of IL-6 and CysC detection for diabetic kidney disease nephropathy in the early stage

Objective To explore the diagnostic value of interleukin-6(IL-6) and serum cystatin-C(CysC) detection for diabetic nephropathy in the early stage. Methods According to urinary albumin excretion rate(UAER),164 diabetic patients were divided into 2 groups.There were 120 diabetic patients without early renal damage(UAER<20μg/min) in DM group;44 patients with diabetic nephropathy(UAER20-200μg/min) in DN group;while 50 healthy persons without diabetes served as the control group.IL-6 and CysC were measured in each group and analyzed statistically. Results Compared with control group,IL-6,CysC and hs-CRP levels were higher in DM and DN groups(P<0.01);compared with DM group,the above three indexes were higher in DN group(P<0.05).The positive rate of combined detection for early renal damage was significantly higher than that of the individual testing(P<0.05);hs-CRP level in positive IL-6 and CysC group was higher than that in negative group(P<0.01). Conclusion IL-6 and CysC detection are helpful to increase the positive rate of detection of diabetic nephropathy,has the important significance for early diagnosis of diabetic nephropathy.CysC and IL-6 detection has important value in judgment of disease activity.