妊娠糖耐量异常患者血脂监测及围生期结局观察

目的探讨妊娠糖耐量异常患者的血脂变化及围生期结局。方法选取2008年1月至2011年6月收治的妊娠糖耐量异常患者94例作为观察组，选取同期收治的健康孕妇95例作为对照组。分别检测两组孕妇的血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL—C）、低密度脂蛋白（LDL—C）各项血脂指标，分析比较两组孕妇的围生期结局。结果观察组空腹血糖、甘油三酯明显高于对照组，观察组血清总胆固醇、高密度脂蛋白、低密度脂蛋白明显低于对照组，观者组围产儿早产、巨大儿、胎儿宫内窘迫、新生儿呼吸窘迫综合征、新生儿低血糖、子痫前期明显高于对照组，血脂异常孕妇围产儿早产、巨大儿、胎儿宫内窘迫、新生儿呼吸窘迫综合征、新生儿低血糖、子痫前期明显高于血脂正常孕妇，差异均显著（P〈0．05）。结论对孕妇进行必要的糖耐量筛查可以及时掌控其血糖和血脂水平。妊娠糖耐量异常患者血脂监测可以作为监测围生期结局的有效指标之一，通过降低患者体内的血脂水平可以大幅减少各种并发症的发生。

Lipid monitoring and perinatal outcome observation in pregnant patients with abnormal glucose tolerance.

Objective To monitor lipid level and investigate perinatal outcome in pregnant patients with abnormal glucose tolerance. Methods Ninety - four pregnant women with abnormal glucose tolerance were selected in the hospital from January 2008 to June 2011 as the ob- servation group, 95 healthy pregnant women were selected during the same period as the control group. Total cholesterol （TC） , triglyceride （ TG）, high density lipoprotein （ HDL - C）, and low density lipoprotein （ LDL - C） were detected in the two groups of pregnant women. The per- inatal outcome of the two groups were compared. Results Fasting blood glucose and TG in the observation group were significantly higher than the control group. Serum TC, HDL - C and LDL - C in the observation group were significantly lower than the control group. Perinatal premature de- livery, fetal distress, macrosomia, neonatal respiratory distress syndrome, neonatal hypoglycemia and preeclampsia in the observation group were obviously higher than the control group ; and they were obviously higher in pregnant women with abnormal lipid level than the pregnant women with normal lipid level （ P 0.05 ） . Conclusion Glucose tolerance screening in pregnant women is helpful for timely control blood glucose and blood lipid levels. Lipid monitoring in patients with abnormal glucose tolerance can be used as an indicator of perinatal outcomes and the occurrence of complications can be substantially reduced by lowering blood lipid levels.