过氧化物酶体增殖物激活受体-γ在炎症性肠病中的表达及意义

目的 观察过氧化物酶体增殖物激活受体-γ(PPAR-γ)在炎症性肠病(IBD)中的表达,探讨其可能的意义.方法 采用免疫组织化学方法检测28例克罗恩病(CD)患者、38例溃疡性结肠炎(UC)患者及30例健康对照肠道组织中PPAR-γ蛋白的表达,并进一步分析PPAR-γ蛋白与IBD临床特征的关系.结果 PPAR-γ在UC患者中表达阳性率为34.21% (13/38),明显低于正常对照63.33%(19/30) 及CD患者60.71%(17/28)(P<0.05);PPAR-γ蛋白表达与UC疾病活动性明显相关(P<0.05),与UC严重程度、病变部位及CD临床特征无明显相关(P>0.05).结论 PPAR-γ蛋白在UC肠道组织中表达降低,且与疾病活动性明显相关.提示PPAR-γ可能在UC发生、发展中发挥重要作用.

Expression of peroxisome proliferator activated receptor gamma in intestinal tissue in patients with inflammatory bowel disease

Objective To investigate the expression and clinical significance of PPAR-γ in intestinal tissue in patients with IBD.Methods Twenty eight patients with Crohn’s disease(CD),thirty eight patients with ulcerative colitis(UC)and thirty normal controls were enrolled.Protein expression of PPAR-γ in IBD intestinal tissue and normal controls was determined by immunohistochemical staining,and its relationship with clinical characteristics was analyzed.Results Compared with normal controls and CD patiants,protein expression of PPAR-γ in intestinal tissue in UC patients was significantly decreased(34.21% vs.63.33% and 60.71% respectively,P<0.05);The expression of PPAR-γ was significantly related with disease activity in UC patients(P<0.05),but not related with severity of disease,site of lesions and CD clinical characteristics.Conclusion Protein expression of PPAR-γ is low in UC patients,and was significant correlate with disease activity,which suggest that PPAR-γ may play an important role in the pathogenesis of UC.