| 提高PLGA微球载蛋白多肽类药物稳定性添加剂的研究进展 |
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| 引用本文： | 陈红丽,王永学,郭伟云,张其清. 提高PLGA微球载蛋白多肽类药物稳定性添加剂的研究进展[J]. 国际生物医学工程杂志, 2012, 35(3): 185-188 |
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| 作者姓名： | 陈红丽 王永学 郭伟云 张其清 |
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| 作者单位： | 1. 干细胞与生物治疗技术中心, 新乡医学院生命科学技术系,453003
2. 300192天津,中国医学科学院北京协和医学院生物医学工程研究所,天津市生物医学材料重点实验室 |
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| 基金项目： | 河南省教育厅自然科学研究计划项目，天津市生物医学材料重点实验室开放课题，河南省医学科技攻关项目 |
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| 摘 要： | 聚乳酸-羟基乙酸共聚物(PLGA)包裹药物制成微球制剂是近年来药物输送体系的研究热点,但是PLGA包囊药物尤其是蛋白多肽类变性失活问题是研究的难点.改进生产工艺特别是使用添加剂可提高微球中包载药物的稳定性.综述了PLGA微球制备及释放过程中不同添加剂的作用特别是稳定蛋白药物的作用.
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| 关 键 词： | 聚乳酸-羟基乙酸共聚物微球 添加剂 稳定性 蛋白多肽类药物 |
Research progress of additives for improving therapeutic peptides and proteins stability in PLGA microspheres |
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| CHEN Hong-li , WANG Yong-xue , GUO Wei-yun , ZHANG Qi-qing. Research progress of additives for improving therapeutic peptides and proteins stability in PLGA microspheres[J]. International Journal of Biomedical Engineering, 2012, 35(3): 185-188 |
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| Authors: | CHEN Hong-li WANG Yong-xue GUO Wei-yun ZHANG Qi-qing |
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| Affiliation: | . Research Center of Stem Cell and Biotherapy Technology, Department of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, China |
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| Abstract: | Microspheres made of poly-lactic-co-glycolic acid （PLGA） have been frequently proposed as drug delivery systems. A very significant challenge in the development of controlled PLGA releasing systems is the instability of drugs especially therapeutic peptides and proteins. Additional approaches, particularly the use of additives, are needed to optimize PLGA delivery of drugs. This article reviews the effects of additives, especially the effects of stabilizing protein during the preparation of PLGA mierosphere and the sustained drug releasing processes. |
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| Keywords: | Poly-lactic-co-glycolic acid microspheres Additive Stability Therapeutic peptides and proteins |
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