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肿瘤的基因靶向检测和治疗
引用本文:郑亚冰,王林,常晓天. 肿瘤的基因靶向检测和治疗[J]. 国际肿瘤学杂志, 2012, 39(3): 186-189
作者姓名:郑亚冰  王林  常晓天
作者单位:山东省医学科学院生物技术研究中心, 济南,250062
摘    要: 随着分子靶向药物和个体化治疗的研发和临床使用,肿瘤的基因靶向检测和治疗已成为肿瘤治疗的热点。尤其是针对表皮生长因子受体(EGFR)信号通路相关基因、DNA复制相关基因、纺锤体形成相关基因、细胞代谢过程相关基因等分子靶向检测和治疗,靶点分子的基因多态性决定了靶向药物治疗的有效性。

关 键 词:  font-size: 10.5pt  color: black"  >  font-size: 10.5pt  color: black  font-family: 宋体  mso-ansi-language: EN-US  mso-fareast-language: ZH-CN  mso-bidi-language: AR-SA  mso-bidi-font-family: 'Times New Roman'  mso-font-kerning: 1.0pt  mso-bidi-font-size: 12.0pt  mso-hansi-font-family: 'Times New Roman'  mso-ascii-font-family: 'Times New Roman'"  >肿瘤  分子诊断技术  抗肿瘤药  

Gene targeting diagnosis and treatment in cancer
ZHENG Ya-bing , WANG Lin , CHANG Xiao-tian. Gene targeting diagnosis and treatment in cancer[J]. Journal of International Oncology, 2012, 39(3): 186-189
Authors:ZHENG Ya-bing    WANG Lin    CHANG Xiao-tian
Affiliation:Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Science, Jinan 250062, China
Abstract:With the development and clinical use of the molecular targeted drugs and individualized treatment, cancer research has been focused on gene targeting diagnosis and treatment. Especially for the epidermal growth factor receptor (EGFR) signaling pathway-related genes, DNA replication-related genes, spindle apparatus format-related genes, cell metabolism-related genes and other molecular targeted detection and treatment, the polymorphism of targeting genes/molecules determines the clinical efficiency of the therapies.
Keywords:Neoplasms  Molecular diagnostic techniques  Antineoplastic agents
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