| 肝细胞生长因子及其受体在多发性骨髓瘤中的研究进展 |
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| 引用本文： | 胡成琳,傅雷华,陈林.肝细胞生长因子及其受体在多发性骨髓瘤中的研究进展[J].国际肿瘤学杂志,2012,39(5):384-386. |
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| 作者姓名： | 胡成琳 傅雷华 陈林 |
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| 作者单位： | 400010,重庆医科大学附属第二医院血液内科 |
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| 摘 要： | 肝细胞生长因子（HGF）是一个多功能的细胞因子，作用于细胞表面的跨膜受体c-Met发挥生物学作用。许多肿瘤的生长、侵袭和转移都与HGF-c-Met信号转导通路异常有关。HGF及其受体c-Met与多发性骨髓瘤（MM）的发生、转移、侵袭及预后关系密切
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| 关 键 词： | 肝细胞生长因子 多发性骨髓瘤 |
Hepatocyte growth factor and its receptor in multiple myeloma |
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| HU Cheng-lin
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FU Lei-hua
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CHEN Lin.Hepatocyte growth factor and its receptor in multiple myeloma[J].Journal of International Oncology,2012,39(5):384-386. |
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| Authors: | HU Cheng-lin FU Lei-hua CHEN Lin |
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| Institution: | Department of Hematology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China |
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| Abstract: | Hepatocyte growth factor （ HGF）, a muhifunctional cytokine, plays a biological role through acting on the cell surface transmembrane receptor c-Mct. The growth, invasion and metastasis of many tumors are associated with the abnormalities of HGF-c-Met signaling pathway. Studies found that HGF and its rcccptor c-Met have close relations with the occurrence, metastasis, invasion and prognosis of multiple myeloma. |
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| Keywords: | Hepatocyte growth factor Multiple myeloma |
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