极性蛋白调控肿瘤发生的分子机制

 上皮细胞具有极性结构，可以形成各种组织和器官，上皮组织通过极性蛋白发挥功能，传递信号。极性蛋白构成和调控上皮组织结构的完整性，建立和维持细胞极性，调节紧密连接和黏附连接；极性蛋白是肿瘤抑制因子，可与原癌基因相互作用，破坏细胞极性，诱导肿瘤发生。上皮细胞极性机制可为临床治疗提供靶点。

Mechanism of polarity proteins regulate tumorigenesis

Epithelial architecture is formed in tissues and organs when groups of epithelial cells are organized into polarized structures. The epithelial function as well as signaling across the epithelial layer is organized by polarity proteins. Epithelial polarity complexes form and regulate epithelial integrity. Polarity proteins establish and maintain cell polarity, regulate tight junctions and adherens junctions. Polarity proteins act as neoplasms suppressors in mammals and interact with oncogenes, disrupt cell polarity, induce tumorigenesis. Therefore, polarity mechanisms of epithelial cell could provid therapeutic targets for clinical therapy.