| 哺乳动物雷帕霉素靶蛋白在胃癌的研究进展 |
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| 引用本文： | 陈小庆,王东旭,袁海滨. 哺乳动物雷帕霉素靶蛋白在胃癌的研究进展[J]. 国际肿瘤学杂志, 2012, 39(3): 222-224 |
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| 作者姓名： | 陈小庆 王东旭 袁海滨 |
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| 作者单位： | 解放军254医院消化内科, 天津,300142 |
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| 摘 要： | 哺乳动物雷帕霉素靶蛋白(mTOR)在调节细胞增殖、生长、能量代谢等方面起重要作用,在很多肿瘤中表达过量,通过mTOR抑制剂雷帕霉素等可以起到抑制胃癌发展的作用。联合mTOR上下游通路研究对胃癌的早期诊断、监测疗效及预后价值更大。
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| 关 键 词： | Times New Roman" ,color: green,font-size: 12pt,mso-font-kerning: 1.0pt,mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体' lang='EN-US'>Gastric neoplasms,Times New Roman" ,color: green,font-size: 12pt,mso-font-kerning: 1.0pt,mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体' lang='EN-US'>Mammalian target of rapamycin, |
Mammalian target of rapamycin in gastric cancer |
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| CHEN Xiao-qing , WANG Dong-xu , YUAN Hai-bin. Mammalian target of rapamycin in gastric cancer[J]. Journal of International Oncology, 2012, 39(3): 222-224 |
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| Authors: | CHEN Xiao-qing WANG Dong-xu YUAN Hai-bin |
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| Affiliation: | Department of Gastroenterology, the 254 Hospital of PLA, Tianjin 300142, China |
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| Abstract: | Mammalian target of rapamycin (mTOR) plays an important role in the regulation of cell proliferation, growth, energy metabolism and so on. Clinical research demonstrate that many tumors have its excessive expression, and the mTOR inhibitors rapamycin can resist the development of gastric cancer. In recent years, research of mTOR signaling pathway combined with its upstream and downstream has larger value for the early diagnosis, monitoring curative effect and prognosis. |
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| Keywords: | Gastric Neoplasms Mammalian target of rapamycin |
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