量子点对体内恶性肿瘤可视化成像研究

量子点(QD)是由Ⅱ～Ⅵ族或Ⅲ～Ⅴ族元素组成的一种纳米微晶体.研究表明,与目前传统荧光标志物相比,QD具有荧光度强、光化学稳定性好和能同时进行多通道成像检测等优良的光学性质,同时QD作为纳米粒还具有易于表面修饰与各种生物分子连接和易于穿透肿瘤新生血管到达癌细胞的性质.因此,QD在对体内肿瘤实时动态可视化靶向成像检测方面具有独特的优势,在对肿瘤个体化诊断和治疗领域中显示出巨大的发展前景.但QD进入体内后的长期生物安全性还需进一步研究.

Visual imaging of quantum dots for in vivo malignancy cancer

Quantum dots (QDs), a kind of nanocrystal, are made from II-VI or III-V group elements. It has been reported that compared with current conventional fluorescent markers, QDs have excellent optical properties such as strong fluorescence, photochemical stability and can be used for simultaneous multi-channel imaging. Meanwhile, as nanoparticle, QDs can be easily surface modified with a variety of biological molecular and can reach cancer cells easily by penetrating the tumor angiogenesis. Therefore, QDs have unique advantages in targeted real-time visual imaging of in vivo tumor and have great prospects in the individual diagnosis and treatment of tumor. However, the long-term biosafety after QDs into the body still needs further study.