| P2Y受体与三叉神经痛之间的关系 |
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| 引用本文： | 赵莉莉,孙晖.P2Y受体与三叉神经痛之间的关系[J].国际口腔医学杂志,2012,39(3):336-338. |
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| 作者姓名： | 赵莉莉 孙晖 |
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| 作者单位： | 安徽医科大学口腔医院口腔颌面外科 |
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| 基金项目： | 国家自然科学基金资助项目,安徽省自然科学基金资助项目 |
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| 摘 要： | 腺苷三磷酸(ATP)作为一种重要的神经递质具有广泛的生物学效应。多种伤害性刺激均可引起三叉神经节(TG)神经元释放ATP,ATP激活P2受体可引起疼痛。P2受体又分为P2X和P2Y两类。在受损的TG神经元上,P2Y受体的表达明显增多。本文就ATP与P2Y受体表达间的相关性、P2Y受体在TG中的信号转导机制、P2Y受体对神经损伤性痛觉信号的转导作用等研究进展作一综述。
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| 关 键 词： | 腺苷三磷酸 P2Y受体 G-蛋白偶联受体 三叉神经痛 |
The relationship between trigeminal neuralgia and P2Y receptors |
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| Zhao Lili
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Sun Hui.The relationship between trigeminal neuralgia and P2Y receptors[J].Journal of International Stomatology,2012,39(3):336-338. |
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| Authors: | Zhao Lili Sun Hui |
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| Institution: | 1.Dept.of Oral and Maxillofacial Surgery,Hospital of Stomatology,Anhui Medical University,Hefei 230032,China;2.Dept.of Physiology,School of Basic Medicine,Anhui Medical University,Hefei 230032,China) |
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| Abstract: | As an important neurotransmitter,adenosine triphosphate(ATP) has a wide range of biological effects.A variety of noxious stimulation can cause trigeminal ganglion neurons releasing ATP,and ATP can induce pain through activation of P2 receptors.P2 receptors can be divided into P2X and P2Y receptors.And P2Y receptors expression significantly increased in impaired trigeminal ganglion neurons.In here,the research progress of the relevance of ATP and the expression of P2Y receptor,the signal transduction mechanisms of P2Y receptor which in TG,and the transduction of P2Y receptor on nerve injury pain signal were reviewed. |
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| Keywords: | adenosine triphosphate P2Y receptor G-protein coupled receptor trigeminal neuralgia |
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