| 细胞微环境介导肿瘤P-糖蛋白的表达调控 |
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| 引用本文： | 黄帆,李远,彭明清.细胞微环境介导肿瘤P-糖蛋白的表达调控[J].国际肿瘤学杂志,2012,39(2):92-95. |
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| 作者姓名： | 黄帆 李远 彭明清 |
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| 作者单位： | 402160, 重庆永川区重庆医科大学附属永川医院中心实验室 |
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| 基金项目： | 重庆医科大学附属永川医院院级课题（YJQN 2011027）； 重庆永川区2011年科技支撑“健康永川”专项基金（YCSTC 2011BF5001） |
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| 摘 要： | P-糖蛋白（P-gp）表达调控与肿瘤多药耐药的发生发展密切相关。肿瘤细胞面临自身微环境内源性损伤及外源性刺激伤害，这些不利的细胞微环境触发细胞应激反应，并通过激活系列信号传导通路调控P-糖蛋白的表达。研究肿瘤细胞内源性微环境与外源性刺激损伤对P-糖蛋白的表达调控将对探寻肿瘤细胞多药耐药获得具有重要意义。
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| 关 键 词： | 肿瘤 P糖蛋白 抗药性 信号传导 |
Expression and regulation of P-glycoprotein mediated by cellular microenvironment in cancer |
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| HUANG Fan
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LI Yuan
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PENG Ming-qing.Expression and regulation of P-glycoprotein mediated by cellular microenvironment in cancer[J].Journal of International Oncology,2012,39(2):92-95. |
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| Authors: | HUANG Fan LI Yuan PENG Ming-qing |
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| Institution: | Central Laboratory, Yongchuan Hospital, Chongqing Medical University,Chongqing 402160, China |
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| Abstract: | Expression and regulation of the P-glycoprotein (P-gp) is associated with the development of multidrug resistance in cancer. Cancer cells are exposed in endogenous damages from its own micro-environments and inflicted stimulated damages. These harmful micro-environments could trigger cellular stress response and regulated the expression of P-gp through various activated signal transduction pathways. Researches of the cellular endogenous micro-environments and exogenous stimulation damages on the expression and regulation of P-gp would have important significance for exploring the multidrug resistance of cancer cell. |
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| Keywords: | Neoplasms P-glycoprotein Drug resistance Signal transduction |
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