帕罗西汀合用复方氯唑沙宗治疗伴抑郁或焦虑状态的紧张型头痛

目的：了解帕罗西汀合用复方氯唑沙宗治疗紧张型头痛的临床疗效。方法：60例紧张型头痛均在服用复方氯唑沙宗基础治疗下,治疗组加服帕罗西汀20～40 mg·d~(-1),对照组加服多塞平25～75 mg·d~(-1),疗程均为12 wk,进行头痛程度、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)评定。结果：治疗组和对照组头痛改善比较无统计学意义(P>0．05)。治疗后4,12 wk,头痛程度评分2组间比较差异均有显著意义(P<0．05)。治疗4 wk和12 wk后的HAMD,HAMA评分治疗组低于对照组(P<0．05,P<0．01)。治疗组的不良反应比对照组少而轻,治疗后2 wk,TESS评分(6±s 3,9±3)2组间比较有非常显著差异(P<0．01)。而治疗后4 wk,12 wk,2组间比较无显著差异(P> 0．05)。结论：帕罗西汀、复方氯唑沙宗联合治疗紧张型头痛的临床疗效较好,不良反应轻。

Paroxetine combined with composite chlorzoxazone in treatment of tension-type headache accompanied with anxiety or depression

AIM:To evaluate the clinical efficacies of combined treatment with paroxetine and composite chlorzoxazone for patients suffered from tension-type headache (TFH).METHODS:Sixty adults with TTH were randomly divided into two groups,with thirty in each.Trial group received paroxetine (20-40 mg.d~(-1)) and control group with doxepin (25-75 mg·d~(-1)) individually both groups were under basic oral composite chlorzoxazone treatment with a course 12 wk.The condition of patients were evaluated at intervals with pain-rat- ing scale,the Hamilton depression (HAMD) scale,Hamilton anxiety (HAMA) scale,and treatment emer- gent symptom scale (TESS).RESULTS:There was no statistical difference on effects of relieve pain between the two groups (P＞0.05).Extent of headache was significantly reduced in trial group comparing with that in control group at 4 and 12 wk after treatment (P＜0.05),together with HAMD and HAMA scales (P＜0.05,P＜0.01).The adverse reactions in trial group were fewer and lighter than those of controls,with TESS (6±3) and (9±3) respectively after 2 wk treatment,showing significant difference (P＜0.01),but with no obvious discrepancy after 4 and 12 wk treatment (P＞0.05).CONCLUSION:Paroxetine combined with composite chlorzoxazone is better efficacies and fewer adverse reactions for treatment of chronic tension-type headache, worthy to be recommanded.