α-氰基丙烯酸酯医用胶在几丁质室修复兔颞骨内面神经缺损中的应用

α-氰基丙烯酸酯医用胶应用于几丁质室修复颞骨内面神经缺损神经固定的可行性及神经再生的效果。方法 成年大耳白兔48只，左耳颞山脚内面神经缺损均用几丁质室桥接，固定颞骨内面神经的方法为实验组采用α-氰基丙烯酸酯医用胶粘合法，对照组采用缝合法及自然放置法，术后1、3个月进行功能测试和组织形态学研究。结果 医用胶粘合作用强，能将颞骨内面神经固定于几丁质室内而不引起几丁质室变形，豁裂；粘合法神经再生成功率高，再生神经纤维排列整齐，密集，功能恢复良好，优于缝合法和自然放置法，结论 几丁质室修复兔颞骨内面神经缺损应用α-氰基丙烯酸酯医用胶固定颞骨内面神经切实可行，方法简便，省时，神经再生质量高。

APPLICATION OF α-CYANOACRYLATE MEDICAL ADHESIVE IN FIXATION OF INTRATEMPORAL FACIAL NERVE WITHIN CHITIN CHAMBER

OBJECTIVE: To study the feasibility of alpha-cyanoacrylate medical adhesive in fixation of intratemporal facial nerve when nerve was repaired within chitin chamber, and to investigate the nerve regeneration. METHODS: Nerve defect of 6 mm was made in left intratemporal facial nerves of 48 rabbits. All the defects were bridged with chitin chamber and were fixed by alpha-cyanoacrylate medical adhesive, surgical suture and natural union. Nerve function test and histomorphological examination were carried out at 1 month and 3 months after repair. RESULTS: It was observed that the nerve was fixed firmly to the chamber with no crack or crease by alpha-cyanoacrylate medical adhesive. The regenerated new nerve fibers were more regular and denser and the neurological function recovered much better in the group fixed by alpha-cyanoacrylate medical adhesive than in the groups those fixed by surgical suture and natural union. CONCLUSION: The medical adhesive is strong in adhesion and beneficial to nerve repair; repair of intratemporal facial nerve defect within chitin chamber fixed by alpha-cyanoacrylate medical adhesive is feasible, simple and timesaving.