Epo/EpoR系统与创伤性颅脑损伤的研究进展

创伤性颅脑损伤（TBI）是导致青壮年患者死亡和长期残疾的主要病因之一。严重颅脑损伤的高死亡率、高致残率给个人、家庭乃至社会带来沉重的负担。如何改善颅脑损伤患者的预后一直是创伤研究的重要课题。近20年的研究发现,促红细胞生成素（Epo）很可能具有改善预后的潜力,该作用由促红细胞生成素受体（EpoR）介导。Epo/EpoR系统在脑保护方面担负着重要的角色。

Progress of Epo/EpoR system and traumatic brain injury

Traumatic brain injury is a leading cause of death in young adults.The high mortality and long-term morbidity of severe traumatic brain injury bring huge burden to the individuals,the family and even the whole society.No medications or procedures have been proven to improve the outcome of severe traumatic brain injury.Over the past twenty years,more and more evidences have revealed that erythropoietin therapy shows the most clinical significance to improve neurological outcomes in patients with severe traumatic brain injury,and its effect is mediated by erythropoietin receptor.It is suggested that the Epo/EpoR system plays a vital role in protecting the brain.