| 丹参多酚酸盐治疗心绞痛的非随机、同期对照临床研究 |
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| 引用本文： | 王侠,李晓庆,吴焕林.丹参多酚酸盐治疗心绞痛的非随机、同期对照临床研究[J].实用医学杂志,2010,26(1). |
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| 作者姓名： | 王侠 李晓庆 吴焕林 |
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| 作者单位： | 广东省中医院二沙分院心脏一科,广州市,510105 |
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| 摘 要： | 目的:评价注射用丹参多酚酸盐治疗冠心病心绞痛的疗效与安全性,并与丹参酮2a磺酸钠注射液进行疗效比较.方法:采用非随机、同期对照临床研究方法;研究对象为稳定性心绞痛患者;对治疗组(注射用丹参多酚酸盐)、对照组(丹参酮2a磺酸钠注射液)的心绞痛疗效、硝酸甘油减退率与心电图疗效进行比较,并进行安全性评价;疗程14 d.结果:治疗组50例,8例中途退出;对照组38例,5例中途退出.两组患者基线资料比较除年龄外经检验差异均无统计学意义.治疗组心绞痛有效率90.5%、硝酸甘油减停率92.3%,对照组心绞痛有效率72.8%、硝酸甘油减停率72.4%,治疗组有效率高于对照组(P ＜ 0.05).治疗组心电图有效率42.9%,对照组36.3%,经检验差异无统计学意义(P ＞ 0.05).结论:注射用丹参多酚酸盐治疗稳定性心绞痛患者安全、有效,心绞痛有效率、硝酸甘油减停率高于丹参酮2a磺酸钠.
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| 关 键 词： | 心绞痛 丹参多酚酸盐 丹参酮2a磺酸钠 |
Salvianolate therapy for angina pectoris |
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| WANG Xia,LI Xiao-qing,WU Huan-lin.Salvianolate therapy for angina pectoris[J].The Journal of Practical Medicine,2010,26(1). |
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| Authors: | WANG Xia LI Xiao-qing WU Huan-lin |
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| Institution: | WANG Xia,LI Xiao-qing,WU Huan-lin. First Division,Department of Cardiology,Ersha Campus,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510105,China |
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| Abstract: | Objective To explore the efficacy and safety of salvianolate therapy for angina pectoris,and to compare the efficacy of salvianolate with that of sulfotanshinone sodium injection. Methods We conducted a nonrandomized,concurrent controlled trial to study salvianolate therapy for stable angina. We assigned the patients to receive salvianolate (study group) or sulfotanshinone sodium (control group)for 14 days,and then compared the efficacy and safety of the therapies,rate of nitroglycerin reduction or disconti... |
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| Keywords: | Angina pectoris Salvianolate Sulfotanshinone sodium |
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