苯那普利对2型糖尿病患者尿铜蓝蛋白及白蛋白的影响

目的　评价苯那普利对 2型糖尿病患者尿铜蓝蛋白 (Cp)及尿白蛋白 (Alb)的影响。 方法　 84例 2型糖尿病患者均分为对照组、控制血压组和苯那普利组。记录及测定受试者的年龄、性别、糖尿病病程、血压、腰围、臀围、腰臀比、身高、体重、体重指数、血糖、糖化血红蛋白、胰岛素、尿素氮、肌酐、尿酸、血脂、血白蛋白 ,并留取晨尿测定铜蓝蛋白、白蛋白及肌酐 (Cr) ,随访 6个月后复查上述指标 ,比较尿Alb/Cr及尿Cp/Cr的变化。 结果　对照组无明显变化 ;控制血压组及苯那普利组尿Alb/Cr和尿Cp/Cr水平均下降 ,苯那普利组尿Cp/Cr下降较控制血压组更明显 (P <0 .0 5 )。结论　苯那普利可降低尿Cp/Cr及尿Alb/Cr。

Effects of benazepril on urinary ceruloplasmin and urinary albumin in type 2 diabetes

Objective To evaluate the effects of benazepril on urinary ceruloplasmin(Cp) and urinary albumin(Alb) in type 2 diabetic patients. Methods To record and determine the following parameters as age,sex,duration of diabetes,blood pressure,waist circumference,hip circumference, waist hip ratio,height,body weight,body mass index(BMI),fasting plasma glucose(FPG),HbA1c,fasting insulin,blood urea nitrogen(BUN),blood creatinine(Cr),uric acid, lipids,serum albumin and early morning urinary ceruloplasmin,albumin and creatinine in 84 type 2 diabetic patients.All the participants were divided into control group, blood pressure interventional group and benazepril interventional group. All parameters mentioned above were assessed after 6 months. Results Urinary Cp/Cr and urinary Alb/Cr both decreased in blood pressure interventional group and benazepril interventional group, but not the control group. Urinary Cp/Cr decreased more obviously in benazepril interventional group than in blood pressure interventional group( P <0.05). Conclusion Benazepril can reduce urinary Alb/Cr and urinary Cp/Cr.