丹参注射液输卵管通液术治疗不孕症

目的:观察宫腔镜下丹参注射液输卵管通液术对输卵管性不孕症患者血液流变学及超敏C-反应蛋白(hs-CRP)的影响。方法:132例输卵管性不孕症患者根据数字表法随机分为两组,对照组(n=65例)采用宫腔镜下输卵管通液术治疗,观察组(n=67例)在对照组治疗基础上加用丹参注射液通液术治疗。比较两组患者治疗前后输卵管通畅率、1年妊娠率及异位妊娠率,检测两组患者血液流变学指标及血清超敏C-反应蛋白(hs-CRP)表达水平变化。结果:两组患者治疗前输卵管通畅率比较差异无统计学意义,治疗后两组输卵管通畅率均明显升高(P0.05),且观察组升高较对照组更为显著(P0.05);两组患者治疗后全血高切黏度、全血低切黏度、血浆黏度、红细胞压积、纤维蛋白原等血液流变学指标及血清hs-CRP表达水平均明显降低(P0.05),且观察组降低较对照组更为显著(P0.05);观察组1年妊娠率明显高于对照组(P0.05),而妊娠时间则明显缩短(P0.05),异位妊娠率明显降低(P0.05)。结论:宫腔镜下丹参注射液输卵管通液术治疗输卵管性不孕症具有改善血液流变学和抗炎作用,疗效较为显著。

Danshen Injection Combined with Fallopian Tube Intubation Deroppilation in Treatment of Oviduct Infertility

Objective: This study aimed to observe the impact of Danshen injection combined with fallopian tube intubation deroppilation under hysteroscopic in the treatment of oviduct infertility on blood rheology and serum hypersensitive C-reactive protein(hs-CRP). Method: In this study, 132 patients with oviduct infertility were randomlydivided into 2 groups. The control group (n=65) was treated with fallopian tube intubation deroppilation under hysteroscopic, while the observation group (n=67) was treated with Danshen injection in addition to the control group therapy. The tubal patency rate, one-year pregnancy rate and ectopic pregnancy rate of the two groups before and after treatment were compared. The blood rheology indexes and expression of hs-CRP of two groups before and after treatment were detected. Result: There was no significant difference in tubal patency rate between the two groups before treatment. The tubal patency rate after treatment in both of the two groups were significantly higher (P<0.05), while the tubal patency rate in observation group increased more than that in control group (P<0.05). The blood rheology indexes and hs-CRP expression levels in the both groups after treatment were significantly lower (P<0.05), while the observation group decreased more than that in the control group (P<0.05). The postoperative of all patients was one year, and the one-year pregnancy rate in observation group was obviously higher than that in control group(P<0.05), while the pregnancy time significantly shortened (P<0.05), and the ectopic pregnancy rate decreased significantly (P<0.05). Conclusion: The treatment of Danshen injection combined with fallopian tube intubation deroppilation under hysteroscopic for oviduct infertility could improve blood rheology and function in anti-inflammation, and the curative effect was significant.