长期配戴软性接触镜后角膜组织的病理改变

目的：探讨配戴不同时间软性接触镜( SCL)后对患者角膜组织的病理变化。
　　方法：应用共焦显微镜分别检查中低度近视SCL组(150例)和对照组(150例)戴镜1,3,5,8,10a以上的中央角膜和周边角膜的变化。
　　结果：戴镜5 a后SCL组中央角膜基底细胞密度低于对照组(P<0.05),上皮层可见微小囊泡及类似角膜营养不良的角膜小滴,上皮下Langerhans细胞密度及神经纤维曲折度大于对照组( P<0.05)。 SCL组中央角膜浅基质层细胞密度低于对照组(P<0.05),各组基质层中白色点状物密度均高于对照组( P<0.05)。 SCL组内皮细胞形态变化明显,但两组内皮细胞密度无差异( P>0.05)。 SCL组中央角膜上皮层厚度小于对照组(P<0.05)。
　　结论：SCL引起角膜组织的改变随戴镜时间的延长逐渐明显,且这种改变不容忽视。

Corneal histopathology changes of the soft contact lens long-time wearers

AIM: To investigate the corneal histopathology changes induced by soft contact lenses(SCL)at diffent time.

METHODS: Central and peripheral cornea structures of myopic patients wearing SCL(150 cases)and the control goups(150 cases)were observed with confocal microscopy. The examinations were performed 1, 3, 5, 8 and 10a after contact lenses wearing respectively.

RESULTS: After wearing the contact lenses for 5a, the cell density of corneal surface epithelial was lower in SCL wearers compared with control goups(P<0.05)and the corneal vesicle and corneal gutata might be occasionally discovered. The density of Langerhans cells both in the central and peripheral cornea was higher in SCL group(P<0.05), and the tortuosity of the nerve fibers was significantly increased in the eye wearing SCL compared with control group. The densities of anterior stromal cells were lower while the microdot densities in the stroma were higher in SCL group than that in control group(P<0.05). The polymorphology of corneal endothelial cells was more obvious in SCL group, but the densities of endothelial cells were similar between two groups(P>0.05). The SCL wearers showed a thinner thickness of central corneal epithelium than control group(P<0.05).

CONCLUSION: The corneal morphologic changes are more obvious with the longer time, and the changes is not ignored.