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| An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis | |
| 引用本文： | 罗丁,韩本立,龚建平,段恒春,李昆. An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis[J]. 中国人民解放军军医大学学报, 1991, 0(4) |
| 作者姓名： | 罗丁 韩本立 龚建平 段恒春 李昆 |
| 作者单位： | Department of Hepatobiliary Surgery Southwest Hospital，Third Military Medical College，Chongqing 630033，Department of Hepatobiliary Surgery，Southwest Hospital，Third Military Medical College，Chongqing 630033，Department of Hepatobiliary Surgery，Southwest Hospital，Third Military Medical College，Chongqing 630033，Department of Hepatobiliary Surgery，Southwest Hospital，Third Military Medical College，Chongqing 630033，Department of Hepatobiliary Surgery，Southwest Hospital，Third Military Medical College，Chongqing 630033 |
| 基金项目： | Supported by National Natural Science Foundation of China,No.38870770 |
| 摘 要： | In order to elucidate the mechanism of liver damage due to acute biliary sepsis,thechanges of hepatocyte mitochondria were observed during biliary sepsis in the rot.Mitochondrial cal-cium content,lysosome fragility of the hepatocytes,lipid peroxide (LPO) level of fiver tissue,omithine carbamyltransferase (OCT),mitochondrial glutamic-oxaloacetic transaminase (m-GOT) andhepatoplastin were determined.It was found that there were overloading of calcium in mitochondria,increase of lysosome fragility,and accumulation of LPO in the liver.These events would result inadverse effects on mitochondrial function The activity of OCT and m-GOT was significantly in-creased,which suggests that mitochondria are seriously damaged since the 2 enzymes mainly comefrom hepatocyte mitochondria.And the liver reserving function declined progressively.Our study indi-cates that mitochondrial damage does exist during acute biliary sepsis,which might playan important role in liver damage. |
An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis |
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| Luo Ding Han Benli Gong Jianping Duan Hengchun Li Kun. An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis[J]. Journal of Medical Colleges of PLA(China), 1991, 0(4) | |
| Authors: | Luo Ding Han Benli Gong Jianping Duan Hengchun Li Kun |
| Affiliation: | Luo Ding Han Benli Gong Jianping Duan Hengchun Li Kun Department of Hepatobiliary Surgery,Southwest Hospital,Third Military Medical College,Chongqing 630033 |
| Abstract: | In order to elucidate the mechanism of liver damage due to acute biliary sepsis,the changes of hepatocyte mitochondria were observed during biliary sepsis in the rot.Mitochondrial cal- cium content,lysosome fragility of the hepatocytes,lipid peroxide (LPO) level of fiver tissue, omithine carbamyltransferase (OCT),mitochondrial glutamic-oxaloacetic transaminase (m-GOT) and hepatoplastin were determined.It was found that there were overloading of calcium in mitochondria, increase of lysosome fragility,and accumulation of LPO in the liver.These events would result in adverse effects on mitochondrial function The activity of OCT and m-GOT was significantly in- creased,which suggests that mitochondria are seriously damaged since the 2 enzymes mainly come from hepatocyte mitochondria.And the liver reserving function declined progressively.Our study indi- cates that mitochondrial damage does exist during acute biliary sepsis,which might play an important role in liver damage. |
| Keywords: | biliary sepsis hepatocyte mitochondrial calcium lysosome fragility lipid peroxides |
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