卡培他滨治疗老年晚期胃癌的临床观察 |
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引用本文: | 陈志勇,郑俊琼,罗建文,黄文金,郑秋香. 卡培他滨治疗老年晚期胃癌的临床观察[J]. 中国实用医药, 2010, 5(22): 37-38 |
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作者姓名: | 陈志勇 郑俊琼 罗建文 黄文金 郑秋香 |
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作者单位: | 福建医科大学附属龙岩市第一医院肿瘤内科,364000 |
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摘 要: | 目的观察卡培他滨治疗老年晚期胃癌的近期疗效及毒副反应。方法我科于2006年12月至2009年12月,应用卡培他滨治疗35例老年晚期胃癌患者,卡培他滨2500mg/m2,每日2次口服,第1~14天;21d为1周期;连用4个周期后评价疗效。结果 35例患者中CR0例(0%)、PR10例(28.57%)、SD13例(37.14%)、PD12例(34.29%)。26例相关症状改善。主要毒副反应为手足综合征、腹泻、血白细胞减少、恶心、呕吐、口腔粘膜炎,但程度均较轻,主要为Ⅰ~Ⅱ度,经对症处理后很快恢复。结论卡培他滨单药治疗晚期胃癌的效果确切,安全有效,可明显改善患者症状,提高患者的生活质量,毒副反应小,患者可以耐受。
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关 键 词: | 卡培他滨 老年 胃癌/进展期 化学疗法 |
Clinical oberservation of capecitabine in treatment of advanced gastric cancer for the elderly patients |
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Affiliation: | CHEN Zhi-yong,ZHENG Jun-qiong,LUO Jian-wen,et al. Department of Medical Oncology of Longyan No. 1 Hospital,Fujian Medical University,Longyan 364000,China |
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Abstract: | Objective To investigate the efficacy and side-effects of capecitabine in treatment of advanced gastric cancer for aged patients. Methods From December 2006 to December 2009,35 evaluable patients with gastric carcinoma received capecitabine ( 2500 mg/m2 po bid) on days 1 ~ 14,the cycles were repeated every 21 days and toxicity were evaluated after 4 cycles. Results In 35 evaluable patients,no cases had complete response ( 0% ) ,10 cases had partial response ( 28. 57% ) ,13 cases had stable disease ( 37. 14%) ,11 cases with progressive disease( 34. 29%). 26 cases had got improved symptoms. The major toxicities were extremity Syndrome,diarrhea,myelosuppression and gastrointestinal response,mainly in I or II degree. Patients were able to recover from these side-effects after the suitable treatments. Conclusion Capecitabine is effective and safe for advanced gastric cancer. It can improve aged patients'living qualities with better symptoms and tolerable side-effects. |
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Keywords: | Capecitabine The elderly Gastric carcinoma/progressive stage Chemotherapy |
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