Behandlung der Gonarthrose |
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Authors: | Prim Dr B F Leeb L Bucsi B Keszthelyi J Böhmova M Valesova R Hawel F Mayrhofer F Singer F Aglas H Bröll |
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Institution: | 1. II. Medizinische Abteilung, N?-Zentrum für Rheumatologie, Humanis-Klinikum Nieder?sterreich, Stockerau 11. II. Medizinische Abteilung, N?-Zentrum für Rheumatologie, Humanis-Klinikum Nieder?sterreich, Landstra?e 18, 2000, Stockerau, ?sterreich 2. Szent Gyoergyi Korhaz Orthopedai Osztaly, Szekesfehervar, Ungarn 3. Baranya Megyei Gyogyfuerdoerkorhaz, Harkany, Ungarn 4. Fakultni nemocnice U Sv. Anny, Brno, Tschechische Republik 5. Fakultni nemocnice Kralovska Vinorhady, Praha, Tschechische Republik 6. Rehabzentrum der PV, Bad Hofgastein, ?sterreich 7. Rehabzentrum der PV, Bad Schallerbach, ?sterreich 8. Rehabzentrum der PV, Laab am Walde, ?sterreich 9. Klinik St. Barbara, Vigaun, ?sterreich 10. II. Medizinische Abteilung mit Rheumatologie und Osteologie, Kaiser-Franz-Josef-Spital im Sozialmedizinischen Zentrum Süd, Wien, ?sterreich
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Abstract: | OBJECTIVE: The aim of this trial was to compare acemetacin (ACE) with celecoxib (CEL) in terms of tolerability and efficacy in the treatment of osteoarthritis of the knee joint. METHODS: A total of 105 patients (26-64 years old) suffering from primary osteoarthritis (OA) of the knee were enrolled in this international, multicenter, randomized, double blind controlled trial. Fifty three patients were given ACE and 52 CEL. They were treated with either 90 mg bid of slow release ACE or 200 mg bid of CEL for 6 weeks. Additional gastroprotective therapy was not provided. Tolerability was assessed by physical examination, laboratory tests, vital signs and reports of side effects, as well as by patient and physician global assessments. Efficacy parameters comprised pain assessment by visual analogue scale (VAS) and ordinal scale, WOMAC, SF-36 and patient and physician global impressions of efficacy. In addition, acetaminophen consumption was recorded. RESULTS: In 21 ACE (39.6%) and 19 CEL patients (36.5%), the number of side effects totaled 56 (ACE n=29; CEL n=27) (ns). Mean pain reduction at week 6 was highly significant ( P<0.0001) in both groups and amounted to 38.7 mm (+/-20.3) in the ACE group and to 35.1 mm (+/-18.7) in the CEL group (ns). Very similar results were seen with respect to the other efficacy parameters. CONCLUSION: ACE is not inferior to CEL for the short-term treatment of knee OA in terms of tolerability and efficacy. |
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