Recent advances in proton pump inhibitors |
| |
Authors: | Tam T Li W Leung-Toung R Karimian K |
| |
Affiliation: | Apotex Research Inc, Medicinal Chemistry Department, 150 Signet Drive, Toronto, Ontario M9L 1T9, Canada. |
| |
Abstract: | Mechanism of action and shortcomings of the approved proton pump inhibitors are reviewed. Advances in the design of new proton pump K(+) and S site inhibitors are presented. Design criteria incorporated into the structure of investigational proton pump inhibitors to address these drawbacks are discussed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|