慢性阻塞性肺疾病急性发作中病毒感染的特点与临床分析

目的 探讨病毒感染在慢性阻塞性肺疾病急性发作(AECOPD)中的特点及其对AECOPD的影响.方法 将176例AECOPD患者、133例COPD稳定期患者、80例健康者分别纳入Ⅰ组、Ⅱ组和健康组,对三组人群进行病毒感染率及病毒特异性抗体检测,并进行组间比较.结果 Ⅰ、Ⅱ组患者的病毒感染率显著高于健康组(P＜0.05),Ⅰ组的IgM阳性率显著高于Ⅱ组和健康组(P＜0.05),Ⅰ、Ⅱ组的IgG阳性率显著高于健康组(P＜0.05).Ⅰ组患者IgM中ADV、RSV阳性率显著高于Ⅱ组和健康组(P＜0.05),Ⅰ、Ⅱ两组患者IgG中ADV、RSV、CMV、HSV均显著高于健康组(P＜0.05).结论 病毒感染与AECOPD关系密切,且病毒潜在的反复感染是CDPD病情的发展恶化的重要因素.

Clinical analysis of virus infection in acute exacerbation of chronic obstructive pulmonary disease

Objective to investigate the clinical effect of virus infection in acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and the feature of virus infection.Methods 176 patients with AECOPD,133 patients in stable stage,80 cases of healthy people were included into groupⅠ,group Ⅱ,and healthy group,infection rate and virus-specific antibodies of three groups were detected and compared.Results Infection rates of groupⅠ and Ⅱ were higher than healthy group(P<0.05),positive rate of IgM in group Ⅰ was higher than that in group Ⅱ(P<0.05),positive rates of IgG in group Ⅰ and Ⅱ were higher than that in healthy group(P<0.05).ADV,RSV,CMV,HSV of IgG in group Ⅰ and Ⅱ were higher than healthy group significantly(P<0.05).Conclusion Virus infection is closely related to AECOPD,and recurrent infections caused by virus are the improtant factors of disease progression in COPD.