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| 食管鳞癌组织中Netrin-1蛋白及mRNA的表达 | |
| 引用本文： | 何章彪,赵琳,王翠侠,陈奎生. 食管鳞癌组织中Netrin-1蛋白及mRNA的表达[J]. 中国实用医药, 2012, 7(29): 1-2 |
| 作者姓名： | 何章彪 赵琳 王翠侠 陈奎生 |
| 作者单位： | 1. 450052,郑州大学第一附属医院病理科/河南省肿瘤病理重点实验室;商丘医学高等专科学校 2. 商丘医学高等专科学校 3. 商丘市第一人民医院 4. 郑州大学第一附属医院病理科/河南省肿瘤病理重点实验室,450052 |
| 摘 要： | 目的 检测食管鳞癌组织中神经轴突导向因子(Netrin-1)及mRNA表达.方法 应用免疫组化SP法和原位杂交方法 检测50例食管鳞癌组织及其相应的19例癌旁不典型增生组织和20例正常食管黏膜组织中Netrin-1、mRNA的表达.结果 ①食管鳞癌组织中Netrin-1、mRNA阳性表达率均高于癌旁不典型增生组织和正常食管黏膜组织(P均<0.05).②有淋巴结转移组食管鳞癌组织中Netrin-1、mRNA阳性表达率均高于无淋巴结转移组(P均<0.05).结论 人食管鳞癌组织中Netrin-1蛋白及mRNA均呈高表达,可能参与食管癌的发生、发展. |
| 关 键 词： | 食管鳞癌 神经轴突导向因子 |
Expression of Netrin-1 protein in esophageal squamous cell carcinoma tissue |
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| Affiliation: | HE Zhang-biao,ZHAO Lin,WANG Cui-xia,et al.Department of Pathology,The First Affiliated Hospital,Zhengzhou University, 450052,China |
| Abstract: | Objective to detect the expression of Netrin-1 protein in squamous cell carcinoma(ESCC) tissue.Methods The expressions of Netrin-1 protein and mRNA,in 50 cases of ESCC,19 cases of adjacent atypical hyperplasia tissue and 20 cases of normal tissue were detected using immunohistocheistry and in situ hybridization. Results The expressions of Netrin-1 protein and mRNA were positive in ESCC tissue. The posive rate of Netrin-1 protein and mRNA in ESCC tissue was significantly higher than those of atypical hyperplasia tissue(P<0.05).In metastatic group,the positive rates of Netrin-1 protein and mRNA in ESCC tissue and atypical hyperplasia tissue was higher than those in non-metastatic group(P<0.05). Conclusion The expression of Netrin-1 protein and mRNA in human ESCC tissue is increased. VEGF and Netrin-1 expression in esophageal cancer lymph node metastasis plays a role. |
| Keywords: | Esophageal squamous cell carcinoma Netrin-1 |
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