年龄,基础FSH、E_2,窦卵泡数预测卵巢反应性的回顾性研究

目的:比较年龄、基础卵泡刺激素(bFSH)、基础雌激素(bE2)、基础窦卵泡数(AFC)预测卵巢反应性的价值。方法:回顾性分析行IVF-ET治疗的736例临床资料。年龄按<35岁、35～岁、38～岁分组;bFSH按<10U/L、≥10U/L分组;AFC按<5个、≥5个分组;bE2按<292.8pmol/L、≥292.8pmol/L分组;分析各项指标与卵巢反应性的关系。结果:年龄、bFSH、AFC各指标不同组卵巢反应性差异均有统计学意义(P<0.001),bE2各组卵巢反应性也有统计学差异(P<0.05)。ROC分析显示,上述4项指标中以AFC预测价值最大,年龄次之。单因素预测时灵敏度低,AFC分别联合年龄、bFSH应用时灵敏度提高。结论:年龄、bFSH、AFC、bE2均能独立预测卵巢反应性,AFC最为重要,可分别联合年龄、bFSH、bE2预测卵巢低反应。

Roles of age, basal levels of follicle-stimulating hormone, estradiol and antral follicle count in the prediction of ovarian response in IVF-ET cycles

Objective:To examine the value of age,basal levels of follicle-stimulating hormone(bFSH),estradiol(bE2) and antral follicle count(AFC) in predicting ovarian response in in vitro fertilization and embryo transfer(IVF-ET) cycles.Methods:A total of 736 patients who had IVF-ET treatment were analysed retrospectively.The patients were divided into different groups according to the age(years <35,35～,38～),levels of bFSH(<10U/L,≥10 U/L),bE2(<292.8pmol/L,≥292.8pmol/L) and AFC(<5,≥5).The relationship between these parameters and ovarian response was examined.Results:The number of oocyte retrieved was significantly correlated with age(P<0.001),bFSH(P<0.001),AFC(P<0.001) and bE2(P<0.05).ROC analysis indicated that AFC was the most sensitive parameter,followed by age.The sensitivity in prediction was relatively low for the single parameter,but highly increased when used in combination.Conclusion:Age,bFSH,bE2 and AFC had their respective value in predicting ovary response,and AFC was the most important one that could predict the poor ovary response when combined with one of the other three parameters.