Immunity against Helicobacter pylori: significance of interleukin-4 receptor alpha chain status and gender of infected mice |
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| Authors: | Aebischer T Laforsch S Hurwitz R Brombacher F Meyer T F |
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| Affiliation: | Department of Molecular Biology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany. aebischer@mpiib-berlin.mpg.de |
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| Abstract: | Vaccination of interleukin-4 (IL-4) receptor alpha (IL-4Ralpha) chain-deficient BALB/c mice with Helicobacter pylori urease and cholera toxin or with urease-expressing, live attenuated Salmonella enterica serovar Typhimurium cells revealed that protection against H. pylori infection is independent of IL-4- or IL-13-mediated signals. A comparison of male and female mice suggests a sexual dimorphism in the extent of bacterial colonization that is particularly evident in the absence of the IL-4Ralpha chain. |
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