Neonatal hypoxia and pulmonary vasospasm: response to tolazoline. |
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Authors: | B W Goetzman P Sunshine J D Johnson R P Wennberg A Hackel D F Merten A L Bartoletti N H Silverman |
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Affiliation: | 1. Department of Pediatrics, University of California, Davis, Calif., USA;2. School of Medicine, Stanford University School of Medicine, Davis, Calif., USA;3. Department of Pediatrics, Stanford University School of Medicine, Davis, Calif., USA |
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Abstract: | Forty-six neonates with hypoxemia were treated with tolazoline, a pulmonary vasodilator, within the first two days of life. Eight of ten (80%) infants without apparent lung disease responded with a mean increase in PaO2 of 116 torr within one hour of beginning tolazoline infusions. One of the responding infants and two nonresponders died. Thirty-six additional infants with a variety of pulmonary disorders had severe hypoxemia which was refractory to mechanical ventilation. Twenty-one (58%) responded with a mean increase in PaO2 of 130 torr within one hour after beginning tolazoline and 13 (62%) of these survived. Fifteen patients had little or no improvement in PaO2 following tolazoline and only three (20%) of these infants survived. Responders could not be distinguished from nonresponders by clinical or laboratory features prior to therapy with tolazoline. Fourteen infants experienced complications possibly related to tolazoline. |
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Keywords: | Reprint address: Department of Pediatrics 4301 X St. Sacramento Calif. 95817. |
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