| 库拉索芦荟对内毒素血症大鼠肾组织损伤的保护作用 |
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| 引用本文： | 何振梅,高笑舸,肖萍,高仲阳. 库拉索芦荟对内毒素血症大鼠肾组织损伤的保护作用[J]. 天津药学, 2003, 15(2): 6-8 |
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| 作者姓名： | 何振梅 高笑舸 肖萍 高仲阳 |
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| 作者单位： | 天津市第一中心医院,天津,300192 |
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| 摘 要： | 目的：观察库拉索芦荟对内毒素血症大鼠肾组织损伤的保护作用。方法：(1)建立大鼠内毒素血症模型。（2）实验动物共分3组，空白对照组，脂多糖(Lipopolysaccharide,LPS)组；芦荟治疗组。观察肾组织的病理学改变及血浆钾（K^ ）、钠（Na^ )、尿素氮（BUN）、肌苷（Cr)的变化，酶联免疫吸附双抗体夹心法测定血浆血管性假血友病因子(vWF)含量。结果：芦荟治疗组的肾组织病理学改变较LPS组轻，未见明显的血浆BUN、Cr的进行性增高，血浆vWF含量明显低于LPS组，结论：库拉索芦荟对内毒素血症大鼠肾组织损伤具有保护作用。
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| 关 键 词： | 库拉索芦荟 内毒素血症 大鼠 肾组织损伤 保护作用 脂多糖 钠 尿素氮 钾 |
| 文章编号： | 1006-5687(2003)02-0006-03 |
| 修稿时间： | 2002-12-19 |
Protection role of Aloe vera L from endotoxemiainjury to rat kidney |
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| He Zhenmei,Cui Wei,Gao Xiaoge,Xiao Ping. Gao Zhongyang. Protection role of Aloe vera L from endotoxemiainjury to rat kidney[J]. Tianjin Pharmacy, 2003, 15(2): 6-8 |
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| Authors: | He Zhenmei Cui Wei Gao Xiaoge Xiao Ping. Gao Zhongyang |
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| Abstract: | Objective: To study the protection role of Aloe vera L from endotoxemia injury to rat kidney. Method: Rat endotoxemia model was established and divided into three groups: the control group, LPS group and Aloe vera L treated group. The pathological change of rat kidney was investigated, plasma K +, Na +, BUN and Cr was determined. Plasma vWF content was measured by EIA. Result: The pathological change of rat kidney in Aloe vera L treated group was less serious than LPS group. In Aloe vera L trated group, no obviously progressive increase of plasma BUN and Cr, plasma vWF content was lower than that in LPS group, Conclusion: Aloe vera L could protect rat kidney from the injury of endotoxemia. |
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| Keywords: | Aloe Endotoxin Vascular endothelial cell |
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