| 消化道肿瘤患者肠道通透性研究 |
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| 引用本文： | 姚玉川,陈村龙,王继德,张亚历,姜泊,熊德鑫. 消化道肿瘤患者肠道通透性研究[J]. 南方医科大学学报, 2004, 24(5): 569-571 |
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| 作者姓名： | 姚玉川 陈村龙 王继德 张亚历 姜泊 熊德鑫 |
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| 作者单位： | 第一军医大学南方医院全军消化病研究所,广东,广州,510515;解放军304医院中心研究室,北京,100037 |
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| 基金项目： | 广东省自然科学基金(01020044)~~ |
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| 摘 要： | 目的测定晚期消化道肿瘤患者肠道通透性的改变,探讨消化道肿瘤是否影响肠粘膜屏障功能。方法健康志愿者、晚期消化道肿瘤患者各16名,每人口服乳果糖、甘露醇液后采集6 h尿样。尿样和乳果糖、甘露醇的标准样经肟化处理后通过气相色谱分析仪进行检测分析。结果甘露醇峰、乳果糖峰出峰时间稳定,峰面积与含量呈线性相关;消化道晚期肿瘤患者与健康志愿者尿样中的乳果糖含量和乳果糖/甘露醇比值存在显著差异(P<0.05),乳果糖含量增高,而甘露醇含量2组无显著差异。结论晚期消化道肿瘤患者肠粘膜通透性增加,存在肠粘膜屏障功能障碍。
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| 关 键 词： | 消化道肿瘤 肠粘膜屏障 肠道通透性 气相色谱 糖探针 |
| 文章编号： | 1000-2588(2004)05-0569-03 |
| 修稿时间： | 2003-11-18 |
Intestinal permeability of patients with advanced digestive tract malignant tumors |
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| YAO Yu-chuan,CHEN Cun-long,WANG Ji-de,ZHANG Ya-li,JIANG Bo,XIONG De-xinInstitute for Digestive Diseases of PLA,Nanfang Hospital,First Military Medical University,Guangzhou ,China, Trauma Research Institute, Hospital of PLA,Beijing ,China. Intestinal permeability of patients with advanced digestive tract malignant tumors[J]. Journal of Southern Medical University, 2004, 24(5): 569-571 |
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| Authors: | YAO Yu-chuan CHEN Cun-long WANG Ji-de ZHANG Ya-li JIANG Bo XIONG De-xinInstitute for Digestive Diseases of PLA Nanfang Hospital First Military Medical University Guangzhou China Trauma Research Institute Hospital of PLA Beijing China |
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| Affiliation: | YAO Yu-chuan1,CHEN Cun-long1,WANG Ji-de1,ZHANG Ya-li1,JIANG Bo1,XIONG De-xin21Institute for Digestive Diseases of PLA,Nanfang Hospital,First Military Medical University,Guangzhou 510515,China, 2Trauma Research Institute,304 Hospital of PLA,Beijing 100037,China |
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| Abstract: | Objective To assess the intestinal barrier function of patients with advanced digestive tract malignant tumors by measuring the changes in intestinal permeability. Methods Sitteen patients with digestive tract tumors and 16 healthy volunteers were enrolled. After oral administration of mannitol and lactulose in deionized water, the 6-hour urine samples were collected for analyzing mannitol and lactulose concentrations using gas-liquid chromatography. Results Urine lactulose concentration and lactulose/mannitol (L/M) ratio of the tumor patients were increased in comparison with those of the healthy subjects (P<0.05). Conclusion The intestinal permeability increased in these tumor patients, indicating intestinal barrier dysfunction. |
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| Keywords: | gut tumor intestinal barrier intestinal permeability gas-liquid chromatography sugar molecular probe |
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