幽门螺杆菌阳性的疣状胃炎治疗112例

目的:了解疣状胃炎与H pylori感染的关系方法:胃镜确诊H pylori阳性的疣状胃炎患者112例随机分组,分别以雷贝拉唑钠、阿莫西林、克拉霉素根除H pylori治疗(A组)和雷贝拉唑钠抑酸治疗(B组).治疗后1 mo评价症状、胃镜改善情况和H pylori根除情况.显效者随访至治疗后6 mo再次评价症状和胃镜改善情况、检测H pylori.结果:治疗1 mo后A组症状和胃镜改善情况明显好于B组,两组比较有显著性差异(89.3% vs 75.0%;91.1% vs 76.8%,P<0.05).所有显效者随访至治疗后6 mo,A组复发率11.1%,B组复发率50.0%,A组明显低于B组.两组复发者H pylori均为阳性,未复发者H pylori阳性率为37.7%,二者对比有显著性差异(P<0.05).结论:疣状胃炎与H pylori感染密切相关.

Treatment of verrucous gastritis with Helicobacter pylori infection:an analysis of 112 cases

AIM:To investigate the relationship between Helicobacter pylori and verrucous gastritis. METHODS:One hundred and twelve patients with verrucous gastritis diagnosed by endos- copy were randomly divided into two groups. All patients had H pylori infection.Patients in group A were treated with rabeprazole,amoxi- cillin and clarithromycin;and patients in group B were treated with rabeprazole and placebo. Treatment duration was 1 wk in both groups. After 1 mo,the clinical symptoms,endoscopic manifestations and H pylori infection were char- acterized. RESULTS:There was a significant difference (89.3% vs 75.0%;91.1% vs 76.8%;P<0.05)in clin- ical symptoms and endoscopic manifestations between group A and group B.All the patients that were clearly in good condition were fol- lowed up at 6 mo,and the relapse rate in group A was lower than that in group B(P<0.05).All relapsing patients were infected with H pylori and had a positive rate of H pylori of 100%.In the non-relapsing patients,the positive rate of H pylori was 37.7%. CONCLUSION:There was a close relationship between H pylori and verrucous gastritis.