颌骨中心性黏液表皮样癌八例的临床病理分析

目的 分析研究8例少见的颌骨中心性黏液表皮样癌(central mucoepidermoid carcinoma of the jaws,CMCJ)临床病理表现,为更合理的治疗提供帮助.方法 对1989年5月至2008年8月间经病理确诊的8例CMCJ(男5例,女3例)的临床表现、影像学特征及组织病理改变进行分析.结果 CMCJ好发于中年,平均发病年龄43.3岁,发生于下颌骨7例,上颌骨1例,下颌骨者多见于磨牙及下颌角升支区.首诊症状多为颌骨肿胀、疼痛或感觉异常、牙齿松动及疼痛,影像学特征多表现为边界清晰或欠清晰的单房或多房放射透光区,光镜下所见与涎腺黏液表皮样癌相似.结论 CMCJ的诊断应基于对病史、临床检查、影像学特征及组织病理学特点的综合分析,特别应注意与一些颌骨囊肿和肿瘤的鉴别.主要治疗方式为原发灶扩大切除术,选择性地结合区域淋巴结清扫以及放化疗可提高治疗效果.

Central mucoepidermoid carcinoma of the jaws:a clinical and pathological analysis of eight cases

Objective To report eight cases of central mucoepidermoid carcinoma of the jaws (CMCJ)and to analyze its clinical and pathological features. Methods Eight cases of central mucoepidermoid carcinoma were diagnosed between 1989 and 2008.The clinical manifestation,radiological and histopathological changes were analyzed.Results The mean age of this group of patients Was 43.3 years,with 5 male and 3 female.Seven cases occurred in mandible,mainly in the molar,angle and ramus areas,and one in maxilla.The first complain usually was local swelling,pain or paraesthesia of the jaw and loosening and pain of the tooth.X-ray displayed unilocular or muhilocular radiolucent lesion with distinct or ill-distinct border,and the light microscopic fingdings were similar to the mucoepidermoid carcinoma originated in the salivary gland.Conclusions To diagnose a CMCJ,it'S necessary to synthetically analyze the case history,clinical xamination,radiological and histopathological features.The treatment is wide local resection Selective neck dissection and radiochemtherapy may improve curative effect and prognosis.