| 培本方调节哮喘大鼠HPA轴紊乱的实验研究 |
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| 引用本文： | 黄琦,刘仁慧,郭忻.培本方调节哮喘大鼠HPA轴紊乱的实验研究[J].上海预防医学,2005,17(12):568-569. |
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| 作者姓名： | 黄琦 刘仁慧 郭忻 |
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| 作者单位： | 上海中医药大学,上海,201203;上海中医药大学,上海,201203;上海中医药大学,上海,201203 |
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| 摘 要： | 目的]研究培本方对哮喘大鼠下丘脑-垂体-肾上腺(HPA)轴紊乱的调节作用。方法]采用卵蛋白(OVA)致敏、激发复制大鼠慢性哮喘模型,以阿斯美胶囊为对照药,通过检测血清皮质酮(CORT)、血浆促肾上腺皮质激素(ACTH)及下丘脑促肾上腺皮质激素释放激素(CRH)含量的变化,探讨培本方对大鼠哮喘模型的影响。结果]模型组较正常组CORT及CRH含量均显著降低,ACTH含量无明显改变;经培本方治疗后,CORT及CRH含量均可明显升高,且培本方高剂量组可使ACTH水平有所增高。结论]培本方抗哮喘作用的机制之一为纠正哮喘HPA轴紊乱。
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| 关 键 词： | 培本方 HPA轴紊乱 哮喘 大鼠 |
| 文章编号： | 1004-9231(2005)12-0568-02 |
| 收稿时间： | 10 20 2005 12:00AM |
| 修稿时间： | 2005年10月20 |
An experimental study on the adjustment of disorder of hypothalamic-pituitary-adrenal axis by Peibenfang in asthmatic rat |
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| HUANG Qi,LIU Ren-hui,GUO Xin.An experimental study on the adjustment of disorder of hypothalamic-pituitary-adrenal axis by Peibenfang in asthmatic rat[J].Shanghai Journal of Preventive Medicine,2005,17(12):568-569. |
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| Authors: | HUANG Qi LIU Ren-hui GUO Xin |
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| Institution: | Shanghai University of TCM , Shanghai 201203 ,China |
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| Abstract: | Objective] To study the adjustment effect of Peibenfang on the disorder of hy pothalamus-pituitary-adrenal(HPA) axis in asthmatics. Methods] Rat asthma model was duplicated by ovalbumin (OVA) through sensitizing and challenging.Asimei capsule was used as medicine for control. By investigating corticosterone(CORT) in blood serum,adrenocorticotropic hormone(ACTH) in blood plasma and CRH in hypothalamus,to explore the effects of Peibenfang on asthma. Results] The levels of CORT and CRH in model group were lower than that in normal group,after treated by Peibenfang,these indexes were increased to different extent. Conclusion] One of the mechanisms of Peibenfang against asthma was to adjust the disorder of HPA axis in asthma. |
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| Keywords: | Peibenfang Disorder of HPA axis Asthma Rat |
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