Comparison of bronchoscopy and computed tomography-guided needle biopsy for re-biopsy in non-small cell lung cancer patients |
| |
| Authors: | Hirohisa Kano Toshio Kubo Kiichiro Ninomiya Eiki Ichihara Kadoaki Ohashi Kammei Rai Katsuyuki Hotta Masahiro Tabata Takao Hiraki Susumu Kanazawa Yoshinobu Maeda Katsuyuki Kiura |
| |
| Affiliation: | 1. Allergy and Respiratory Medicine, Okayama University Hospital, 2-5-1, Kita-ku, Shikata-cho, Okayama City, Okayama, Japan;2. Center for Clinical Oncology, Okayama University Hospital, 2-5-1, Kita-ku, Shikata-cho, Okayama City, Okayama, Japan;3. Hospital-based Cancer Registry Division, Okayama University Hospital, 2-5-1, Kita-ku, Shikata-cho, Okayama City, Okayama, Japan;4. Center for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1, Kita-ku, Shikata-cho, Okayama City, Okayama, Japan;5. Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Kita-ku, Shikata-cho, Okayama City, Okayama, Japan;6. Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Kita-ku, Shikata-cho, Okayama City, Okayama, Japan;1. Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Tochigi, Japan;2. Division of Pulmonary Medicine, Department of Thoracic Surgery, Jichi Medical University, Tochigi, Japan;1. Department of Respiratory Medicine, Ichinomiya-nishi Hospital, Ichinomiya, Japan;2. Department of Radiology, Ichinomiya-nishi Hospital, Ichinomiya, Japan;1. Kanagawa Cardiovascular and Respiratory Center, Department of Respiratory Medicine, Tomioka-Higashi 6-16-1, Kanazawa-ku, Yokohama, 236-0051, Japan;2. University of Yamanashi Hospital, Department of Internal Medicine 2, Shimokato 1110, Chuo-shi, Yamanashi, 409-3898, Japan;1. Department of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Japan;2. Department of Laboratory of Pathology, Nagasaki University Hospital, Nagasaki, Japan;3. Department of Radiology, Kansai Rosai Hospital, Amagasaki, Japan;1. Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan;2. Nakajima Medical Clinic, 1-8-3 Mikagenakamachi, Higashinada-ku, Kobe, 658-0054, Japan;3. I&H Co.,Ltd, 1-7-20, Mikagenakamachi, Higashinada-ku, Kobe, 658-0054, Japan |
| |
| Abstract: | BackgroundNew therapeutic drugs have been developed for non-small cell lung cancer (NSCLC), and the prognosis of advanced NSCLC patients has improved. However, resistance to these drugs is a concern, and re-biopsy is necessary to determine the mechanism of drug resistance. There are many reports about the protocols for re-biopsy, including techniques such as bronchoscopy and computed tomography-guided needle biopsy (CTNB); however, there is no consensus on which method is optimal. Therefore, we retrospectively reviewed the bronchoscopy and CTNB re-biopsies conducted at our hospital.MethodsWe retrospectively analyzed 79 cases of re-biopsies with bronchoscopy or CTNB in patients with NSCLC from January 2014 to December 2016 at our institute.ResultsForty-nine cases of bronchoscopy and 30 cases of CTNB were taken for re-biopsy. The diagnostic rates of bronchoscopy and CTNB were 83.7% and 100%, respectively (p = 0.023). The complication rates of bronchoscopy and CTNB were 18.4% and 36.7%, respectively (p = 0.11), with a statistically significant difference in the incidence of pneumothorax (0% vs. 23.3%, respectively; p < 0.01). Pneumothorax required drainage in 6.7% of all CTNB cases. There were no fatalities in either group.ConclusionsCTNB showed a higher diagnostic rate; however, it was associated with a higher rate of complications such as pneumothorax. Hence, the optimal modality must be determined individually for each patient. |
| |
| Keywords: | Bronchoscopy Non-small cell lung cancer Computed tomography-guided needle biopsy Re-biopsy |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
