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Spontaneously regressed granulomatosis with polyangiitis: A case report
Authors:Hiroki Ota  Chisa Sato  Akira Igarashi  Sumito Inoue  Sakiko Masuda  Akihiro Ishizu  Masafumi Watanabe
Affiliation:1. Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan;2. Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo 060-0812, Japan;1. Department of Respiratory Medicine, Yodogawa Christian Hospital, Osaka, Japan;2. Department of Respiratory Medicine, Iizuka Hospital, Iizuka, Japan;1. Department of Medicine, School of Medicine, Chiba University, Chiba 260-8670, Japan;2. Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan;3. Health Professional Development Center, Chiba University Hospital, Chiba 260-8670, Japan;4. Department of Pulmonary Medicine, School of Medicine, International University of Health and Welfare, Chiba 286-8686, Japan;5. Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan;6. Department of Pathology, Chiba University Hospital, Chiba 260-8670, Japan;7. Department of Hematology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo 113-8677, Japan;8. Department of Hematology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan;9. Department of Hematology, School of Medicine, International University of Health and Welfare, Chiba 286-8686, Japan;1. Tropical Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt;2. Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt;3. Chest Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Abstract:A 71-year-old woman presented with chest pain, cough, and back pain. A chest roentgenogram showed multiple nodular shadows in both lungs. She was diagnosed with granulomatosis with polyangiitis (GPA). The multiple nodular shadows in both lungs regressed spontaneously in a few months. There are few reports of spontaneous regression of GPA, and the underlying mechanism is unclear. Neutrophil extracellular traps (NETs) have been recently shown to be involved in GPA. NETs may also be related to the natural regression of GPA.
Keywords:Granulomatosis with polyangiitis  Myeloperoxidase-antineutrophil cytoplasmic antibody  Neutrophil extracellular traps  Spontaneous regression
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