IMPORTANCE OF PROSTATIC SPECIFIC ANTIGEN (PSA) IN CLINICAL PRACTICE : OUR EXPERIENCE |
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| Authors: | GS CHOPRA RK BINDAL SV KOTWAL R RAI JR BHARDWAJ |
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| Affiliation: | *Classified Specialist Pathology & Transplant Immunologist, Army Hospital (RR) Delhi Cantt-10;+Post Graduate Trainee (Pathology), Army Hospital (RR) Delhi Cantt-10;#Senior Advisor Urology. Army Hospital (RR) Delhi Cantt-10;**Professor and Head of Department of Pathology AFMC Pune;++Commandant AFMSD, Delhi Cantt |
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| Abstract: | A total of 89 patients in the age group of 50-92 years having different histopathologically proven prostatic conditions were analysed with prostate specific antigen (PSA) and clinical co-relation undertaken. PSA levels were found to be significantly higher (p < 0.05) in 48 carcinoma prostate cases (mean 93.16 ± 50.75 ng/ml) as compared to 32 benign prostatic hyperplasia (mean 4.66 ± 3.85 ng/ml). Similarly, levels were considerably reduced in 15 post-operative adenocarcinoma cases (mean 10.77 ± 9.65 ng/ml) as compared to their pre-operative samples (mean 93.16 ± 60.75 ng/ml). PSA levels were moderately higher in 9 cases of prostatitis (mean 13.28 ± 4.53 ng/ml). A very high degree of sensitivity, specificity and positive predictive value of PSA e.g. 95.8%, 75.6% and 82.2% respectively was found in adenocarcinoma cases, when levels of PSA were > 10 ng/ml. Thus it necessitates a detailed and thorough examination in such cases to come to final conclusion and early management of the cases.KEY WORDS: Prostatic Specific Antigen (PSA) |
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