Ultrastructural cytochemical study of enzymes expressed by signet ring cells in gastric cancer |
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Authors: | Guang-Lin Yang Yu-Ming Dong Wei-Dong Du Ying-Hao Su Hong Zhang Ji-Fen Wu Dao-Bin Wang Ai-Lian Xu |
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Institution: | Guang-Lin Yang, Yu-Ming Dong, Wei-Dong Du, Ying-Hao Su, Hong Zhang, Ji-Fen Wu, Dao-Bin Wang, Ai-Lian Xu, Department of Pathology, Anhui Medical University, Hefei 230032, Anhui Province, China |
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Abstract: | AIM: To study the ultrastructural localization of five marker enzymes (ALPase, ACPase, G6Pase, TPPase and CCOase) in gastric cancer signet ring cells to demonstrate their biologic behaviors.METHODS: Five marker enzymes were examined in signet ring cells of seven gastric cancer patients by ultrastructural enzyme cytochemical techniques.RESULTS: The number of corresponding organelles and the activities of marker enzymes, especially ACPase and TPPase, increased, leading to stronger mucus synthesis, secretion and digestion in gastric cancer signet ring cells. There was a lack of collagenous fibers in the stroma around the cancer nests.CONCLUSION: Signet ring cell carcinoma is very invasive with metastasis rates due to the secretion of proteolytic enzymes. |
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Keywords: | Stomach neoplasms/enzymology Carcinoma signet ring cell/enzymology Alkaline phosphatase/analysis Acid phosphatase/analysis |
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