Implication of HLA-DMA Alleles in Corsican IDDM |
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| Authors: | P Cucchi-Mouillot S Lai C Carcassi P Sorba M Stuart-Simoni J-P Amoros B Genetet D Haras L Contu |
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| Institution: | 1.CEVAREN, Université de Corse, Campus Grossetti, 20250 Corte, France;2.Cattedra di Genetica Medica, Università di Cagliari, via San Giorgio 12, 09124 Cagliari, Italia;3.Centre Hospitalier Général d’Ajaccio, 20000 Ajaccio, France;4.Groupe Universitaire de Recherche en Immunologie et Immunopathologie, EA 1257, Université Rennes I, 2 av. du AR. Léon Bernard, 35 043 Rennes, France |
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| Abstract: | The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and IDDM, in a Corsican population. The DMA*0101 allele was observed to confer a significant predisposition to this autoimmune disease while the DMA*0102 allele protected significantly. Experiments examining polymorphism of the HLA-DRB1 gene established that these relationships are not a consequence of linkage disequilibrium with HLA-DRB1 alleles implicated in this pathology. The study of the DMA gene could therefore be an additional tool for early IDDM diagnosis in the Corsican population. |
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| Keywords: | diabetes HLA-DMA Corsica |
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