T2-weighted Dixon MRI of the spine: A feasibility study of quantitative vertebral bone marrow analysis |
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| Authors: | Ricardo Donners Anna Hirschmann Andreas Gutzeit Dorothee Harder |
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| Institution: | 1. Department of Radiology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland;2. Institute of Radiology and Nuclear Medicine and Breast Center St. Anna, Hirslanden Klinik St. Anna, 6006 Lucerne, Switzerland;3. Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, 8093 Zurich, Switzerland;4. Department of Radiology, Paracelsus Medical University, 5020 Salzburg, Austria |
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| Abstract: | PurposeTo compare the measurements of fat fraction (FF) and in-phase vs. opposed-phase ratio between two-dimensional T2-weighted (T2W) spin-echo (SE) Dixon and three-dimensional (3D) T1-weighted (T1W) volume interpolated breath-hold examination (VIBE) Dixon sequences in malignant vertebral lesions and normal vertebral bone marrow.Materials and methodsThirty patients with focal vertebral malignancies (20 men, mean age, 67.3 ± 9.4 SD] years; age range: 41–84 years) and 30 patients without malignant spinal disease (11 men, mean age, 70.1 ± 12.9 SD]; age range: 53–93 years) were retrospectively included. Each patient underwent spine MRI at 1.5 Tesla including T2W SE and T1W VIBE 2-point Dixon sequences. Two readers independently performed 3D-volume of interest (VOI) and region of interest (ROI)-based FF and IO-ratio measurements of malignant lesions and normal vertebrae. Student t-test, Pearson correlation (r) test and two-way mixed model intraclass correlation coefficients (ICC) were used to compare measurements.ResultsT2W SE and T1W VIBE mean FF and IO-ratio were significantly smaller in malignancy compared to normal marrow, but there were significant differences of paired measurement mean values between T2W SE and T1W VIBE Dixon parameters in malignant lesions T2W SE VOI FF = 9%, T2W SE ROI FF = 7%, T2W SE IO-ratio = 4% vs. T1W VIBE VOI FF = 11%, T1W VIBE ROI FF = 9%, T1W VIBE IO-ratio = ?2%, and in normal vertebrae T2W SE VOI FF = 74%, T2W SE ROI FF = 77%, T2W SE IO-ratio = 51% vs. T1W VIBE VOI FF = 67%, T1W VIBE ROI FF = 73%, T1W VIBE IO-ratio = 58% (each P comparing the paired T2W TSE and T1W VIBE parameter, respectively < 0.001). There was excellent positive correlation between T2 W SE and T1 W VIBE-FF (r ≥ 0.99) and VOI and ROI FF measurements for each sequence (r ≥ 0.99). Inter-reader agreement was excellent for all measurements (ICC ≥ 0.94 for all).ConclusionCalculation of T2W SE Dixon derived FF is feasible and gave valid results that help discriminate between malignant vertebral lesions and normal vertebral bone marrow. |
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| Keywords: | Spine Neoplasm Metastasis Magnetic resonance imaging 2D"} {"#name":"keyword" "$":{"id":"kw0030"} "$$":[{"#name":"text" "_":"Two-dimensional 3D"} {"#name":"keyword" "$":{"id":"kw0040"} "$$":[{"#name":"text" "_":"Three-dimensional CI"} {"#name":"keyword" "$":{"id":"kw0050"} "$$":[{"#name":"text" "_":"Confidence interval DWI"} {"#name":"keyword" "$":{"id":"kw0060"} "$$":[{"#name":"text" "_":"Diffusion weighted imaging FF"} {"#name":"keyword" "$":{"id":"kw0070"} "$$":[{"#name":"text" "_":"Fat fraction FO"} {"#name":"keyword" "$":{"id":"kw0080"} "$$":[{"#name":"text" "_":"Fat-only ICC"} {"#name":"keyword" "$":{"id":"kw0090"} "$$":[{"#name":"text" "_":"Intraclass correlation coefficient IO-ratio"} {"#name":"keyword" "$":{"id":"kw0100"} "$$":[{"#name":"text" "_":"In-/opposed-phase ratio Ip"} {"#name":"keyword" "$":{"id":"kw0110"} "$$":[{"#name":"text" "_":"In-phase MRI"} {"#name":"keyword" "$":{"id":"kw0120"} "$$":[{"#name":"text" "_":"Magnet resonance imaging OP"} {"#name":"keyword" "$":{"id":"kw0130"} "$$":[{"#name":"text" "_":"Opposed-phase RIS"} {"#name":"keyword" "$":{"id":"kw0140"} "$$":[{"#name":"text" "_":"Radiology information system ROI"} {"#name":"keyword" "$":{"id":"kw0150"} "$$":[{"#name":"text" "_":"Region of interest SE"} {"#name":"keyword" "$":{"id":"kw0160"} "$$":[{"#name":"text" "_":"Spin-echo T1W"} {"#name":"keyword" "$":{"id":"kw0170"} "$$":[{"#name":"text" "_":"T1-weighted T2W"} {"#name":"keyword" "$":{"id":"kw0180"} "$$":[{"#name":"text" "_":"T2 weighted TSE"} {"#name":"keyword" "$":{"id":"kw0190"} "$$":[{"#name":"text" "_":"Turbo spin-echo VIBE"} {"#name":"keyword" "$":{"id":"kw0200"} "$$":[{"#name":"text" "_":"Volume interpolated breath-hold examination VOI"} {"#name":"keyword" "$":{"id":"kw0210"} "$$":[{"#name":"text" "_":"Volume of interest WO"} {"#name":"keyword" "$":{"id":"kw0220"} "$$":[{"#name":"text" "_":"Water-only |
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