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Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cell transplantation improves hypoxic-ischemic brain injury |
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| Authors: | Dengna Zhu Yanjie Jia Jun Wang Boai Zhang Guohui Niu Yazhen Fan Rehabilitation Treatment Center for Children with Cerebral Palsy of Henan Province Third Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province China |
| Institution: | Dengna Zhu1,Yanjie Jia2,Jun Wang1,Boai Zhang2,Guohui Niu1,Yazhen Fan1 1Rehabilitation and Treatment Center for Children with Cerebral Palsy of Henan Province,Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China 2Department of Neurology,First Affiliated Hospital of Zhengzhou University,China |
| Abstract: | Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cells were transplanted into a hypoxic-ischemic neonatal rat model via the tail vein. BrdU-positive cells at day 7 post-transplantation, as well as nestin- and neuron specific enolase-positive cells at day 14 were increased compared with those of the single neural stem cell transplantation group. In addition, the proportion of neuronal differentiation was enhanced. The genetically modified cell-transplanted rats exhibited enhanc... |
| Keywords: | human insulin-like growth factor 1 neural stem cell hypoxic-ischemic brain damage transplantation neural regeneration |
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